. The human IGF2 gene is autosomal and maternallyimprinted. Copies of the gene received from themother are not expressed, but copies received fromthe father are expressed. You have found two allelesof this gene that encode two different forms of theIGF2 protein distinguishable by gel electrophoresis.One allele encodes a 60K (Kilodalton) blood protein;the other allele encodes a 50K blood protein. In ananalysis of blood proteins from a couple named Billand Joan, you find only the 60K protein in Joan’sblood and only the 50K protein in Bill’s blood. Youthen look at their children: Jill is producing only the50K protein, while Bill Jr. is producing only the 60Kprotein.a. With these data alone, what can you say about theIGF2 genotype of Bill Sr. and Joan?b. Bill Jr. and a woman named Sara have two children, Pat and Tim. Pat produces only the 60K protein and Tim produces only the 50K protein. Withthe accumulated data, what can you now say aboutthe genotypes of Joan and Bill Sr.?
. The human IGF2 gene is autosomal and maternally
imprinted. Copies of the gene received from the
mother are not expressed, but copies received from
the father are expressed. You have found two alleles
of this gene that encode two different forms of the
IGF2 protein distinguishable by gel electrophoresis.
One allele encodes a 60K (Kilodalton) blood protein;
the other allele encodes a 50K blood protein. In an
analysis of blood proteins from a couple named Bill
and Joan, you find only the 60K protein in Joan’s
blood and only the 50K protein in Bill’s blood. You
then look at their children: Jill is producing only the
50K protein, while Bill Jr. is producing only the 60K
protein.
a. With these data alone, what can you say about the
IGF2 genotype of Bill Sr. and Joan?
b. Bill Jr. and a woman named Sara have two children, Pat and Tim. Pat produces only the 60K protein and Tim produces only the 50K protein. With
the accumulated data, what can you now say about
the genotypes of Joan and Bill Sr.?
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