1. A student, halfan hour after the dinner, containing about 150 g of carbohydrates, 20 g of fat, and 40 g of protein, is sitting in a chair and reading. What metabolic changes occur in this state? For answer:
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- 2. A girl decided to lose wcight and has been fasting for three days. What metabolic changes occurred in the girl's organism by the end of the 3-day fast? For answer: a) draw appropriate charts of metabolic pathways reflecting the changes in fat metabolism in the liver and adipose tissue during the prolonged fasting; b) name the hormones that accelerate these processes, and draw the charts of signal transduction of these hormoncs to the target cells; c) enumerate the regulatory enzymes with changed activity under the influence of the mentioned hormones.1. A person ate 200 g of carbohydrates and then did not eat anything for a day. What process of carbon metabolism was stimulated in the liver 14 hours after the last meal? For answer: a) write a diagram of the process that speeds up in the liver after 14 hours after cating; b) indicate the regulatory reactions and their enzymcs; c) describe the mechanism of signal transduction by a hormone that regulates this metabolic pathway.3. A patient has got excess carbohydrate meal for the years and gain the weight. To explain this: a) draw the schemes of TAG synthesis in the liver; b) describe the transport of TAG from the liver to adipose tissue; c) describe the functions of insulin in the conversion of glucose to TAG in the liver and adipose tissue. Glucose containing Catoms was added to isolated hepatocytes inanexperiment. Ifthe glucose was added in excess, the rate of triacylglyccrol synthesis increased.
- 3. After 12 days of starvation, a man reduced his weight by 4 kg. The doctor prescribed him biochemical blood test to analyze the level of lipids in serum blood. The results showed an elevated level of free fatty acids and triacylglycerols. Explain the results of the biochemical blood test. For that: a) name the main hormone which manages metabolism during starvation; b) draw the scheme of this hormone action on the adipose tissue; c) name the possible pathways of fatty acids usage in the liver during starvation and write down the proper schemes.Patient who had undergone a complex maxillofacial operation could not takefood during 2 days, but glucose level in the patient's blood during that period wason the lower limit of normal. What mechanisms facilitate the maintenance ofnormal level of glucose in prolonged starvation? To answer this question:a) indicate normal fasting blood glucose level;b) draw the metabolic pathway ensuring glucose synthesis in patient's body duringa period of starvation, mark the enzymes and coenzymes;c) list the substrates of this process and its localization.In NOT MORE than 350 words, distinguish between the metabolic concepts presented by the terms: i. fed state, ii. fasted state/in-between meals, and iii. extended fasting/starvation. Your response should highlight the energy status of cells under these conditions, preferred fuels, predominant metabolic pathways, and hormonal effects on cellular processes.
- The Cori cycle involves the: OA) conversion of glucose to lactate in liver and lactate to glucose in muscle. OB) conversion of glucose to pyruvate in muscle and pyruvate to glucose in liver. OC) conversion of glucose to lactate in muscle and lactate to glucose in liver. O conversion of lactate to acetoacetate in muscle and ketone bodies to glucose in brain. D)How is a condition such as diabetes a good example of the failure of a set point in humans?Distinguish between the metabolic concepts present by the terms: i. Fed state ii. Fasted state/in-between meals iii. Extended fasting/starvation. Your response should highlight the energy status of cells under these conditions, preferred fuels, predominant metabolic pathways, and hormonal effects on cellular processes.
- B) Read the situations below and indicate which of the four methods of enzyme regulation is occurring for each. a) The energy-carrying molecule ATP is made by the enzyme ATP synthase. Muscle cells use a lot of energy and also have higher amounts of the ATP synthase enzyme than many ouier cem types. General mechanism of enzyme regulation: /1 b) Prostaglandins are messenger molecules involved in the inflammatory response, as well as th perception of pain. They are synthesized from polyunsaturated fatty acid substrates by an enzyn called cyclo-oxygenase. "Ibuprofen" is the active ingredient in a variety of anti-inflammatory medications such as Motrin® and Advil®. It reduces pain and swelling by binding to a hydrophobic channel in the active site of cyclo-oxygenase, blocking the polyunsaturated fatty acids from binding to the enzyme, and therefore stopping production of prostaglandins. General mechanism of enzyme regulation: a) In point form, describe the steps by which ATP is produced…21. The body is capable of catabolizing many substances as sources of energy. Which of the following would be used as an energy source only after the depletion of other sources and the person is yet not getting any external source of food? A) fat in adipose tissue B) glucose in the blood C) protein in muscle cells D) glycogen in muscle cells E) calcium phosphate in bone 22. Using anatomical terminology, identify the correct order of words that make this a true statement: kidney extends slightly more than the D) left; inferiorly; right E) right; anteriorly; left The kidney. A) right; superiorly; left B) right; inferiorly; left C) left; superiorly; right 23. Most reabsorption of substances from the glomerular filtrate occurs in the: A) glomerulus B) collecting tubule C) proximal convoluted tubule D) ureter E) distal convoluted tubule 24. In which parts of the GIT does digestion happen? A) Mouth B) Esophagus G) Stemach D) Intestine E) A, C, D are correct F) A & B onlyWhich 2 endocrine glands exert the most control over blood calcium level:a) anterior pituitary and adrenal cortex b) thyroid and ovaries c) adrenal cortex and thyroid d) parathyroid and anterior pituitary e) thyroid and parathyroidWhat is the role of calcium at the synaptic terminal?Explain the active site theory of enzyme functioning?