10. A scientist working in a research aboratory has been examining different agonists of serotonin receptor 1B (5-HT1B), a G-protein-coupled re- ceptor. Compound A has a much higher affin- ty for 5-HT1B than compound B. Both com- pounds have a higher affinity for the reсeptor chan serotonin. Which of the following de- scribes the relationship between

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Chapter39: Information Flow And The Neuron
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Problem 6TYK: In the propagation of a nerve impulse: a. the refractory period begins as the K+ channel opens,...
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10. A scientist working in a research
laboratory has
been examining different agonists of
serotonin
receptor 1B (5-НT1B), а
G-protein-coupled re-
ceptor. Compound A has a much higher
affin-
ity for 5-HT1B than compound B. Both
com-
pounds have a higher affinity for the
receptor
than serotonin. Which of the following
de-
scribes the relationship between
compound A
and compound B when considering the
guan-
ine-nucleotide exchange activity of
5-HT1B?
(A) Km for the exchange reaction with
com-
pound A is higher than that with com-
pound B
(B) Km for the exchange reaction with
com-
pound A is lower than that with
compound
(C) Km values with compounds A and B
Transcribed Image Text:10. A scientist working in a research laboratory has been examining different agonists of serotonin receptor 1B (5-НT1B), а G-protein-coupled re- ceptor. Compound A has a much higher affin- ity for 5-HT1B than compound B. Both com- pounds have a higher affinity for the receptor than serotonin. Which of the following de- scribes the relationship between compound A and compound B when considering the guan- ine-nucleotide exchange activity of 5-HT1B? (A) Km for the exchange reaction with com- pound A is higher than that with com- pound B (B) Km for the exchange reaction with com- pound A is lower than that with compound (C) Km values with compounds A and B
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