3. You are studying an interaction between an antibody and the antigen shown below. The amine next to the benzene ring has a pKa of 10.5 and the carboxylic acid has a pKa of 4.2. Circle each of these functional groups on the molecule below. (b) NH₂ HO B. Draw the structure of the antigen at pH 7.4. pra Yantela sble OH V N 148 M3 المهم له (9) vionA EAM C. There is one ionic bond and 3 hydrogen bonds that occur between the antibody and antigen. The ionic bond forms between a glutamate on the antibody and the protonated amine of the antigen. One of the hydrogen bond forms between a serine side chain on the antibody and the carboxylic acid of the antigen. Draw the ionic bond, including the full chemical structure of the side chain of the antibody. Indicate the ionic bond with a wavy line. D. A mutation occurs in the antibody such that the serine described above changes to an alanine. Do you expect the antigen to bind more or less tightly in the mutant compared to the original? Briefly explain.
3. You are studying an interaction between an antibody and the antigen shown below. The amine next to the benzene ring has a pKa of 10.5 and the carboxylic acid has a pKa of 4.2. Circle each of these functional groups on the molecule below. (b) NH₂ HO B. Draw the structure of the antigen at pH 7.4. pra Yantela sble OH V N 148 M3 المهم له (9) vionA EAM C. There is one ionic bond and 3 hydrogen bonds that occur between the antibody and antigen. The ionic bond forms between a glutamate on the antibody and the protonated amine of the antigen. One of the hydrogen bond forms between a serine side chain on the antibody and the carboxylic acid of the antigen. Draw the ionic bond, including the full chemical structure of the side chain of the antibody. Indicate the ionic bond with a wavy line. D. A mutation occurs in the antibody such that the serine described above changes to an alanine. Do you expect the antigen to bind more or less tightly in the mutant compared to the original? Briefly explain.
Chapter10: Reconstitution Of Powdered Drugs
Section: Chapter Questions
Problem 3.4P
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