4) Propanoic acid is a carboxylic acid. List four other propionic acid derivatives, and rank them in order of their expected reactivity toward nucleophilic acyl substitution. [self-study not grade: Which one is most likely used in Friedel-Crafts acylation? Which one is most likely used in alkylation reaction involving base (to deprotonate a-hydrogen) and alkyl halide? Why? What would an amide be synthetically useful for? ]

4) Propanoic acid is a carboxylic acid. List four other propionic acid derivatives, and rank them in order of their expected reactivity toward nucleophilic acyl substitution. [self-study not grade: Which one is most likely used in Friedel-Crafts acylation? Which one is most likely used in alkylation reaction involving base (to deprotonate a-hydrogen) and alkyl halide? Why? What would an amide be synthetically useful for? ]

Organic Chemistry

8th Edition

ISBN:9781305580350

Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Chapter24: Catalytic Carbon-carbon Bond Formation

Section: Chapter Questions

Problem 24.26P: The compound eutypine is an antibacterial agent isolated from the fungus Eutypa lata. This fungus...

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