4) Which level of protein structure would be most affected by the following changes... a) mutation from isoleucine to valine b) oxidation of two cysteine sidechains c) PrP (healthy prion protein, mostly a-helical) changes to PrP* (infectious form, mostly ß-strand) (more than one answer!) d) increase in pH from 7 to 10 5) Decide on the most likely mode of denaturation for each of the following compounds... a) hexane (organic solvent) b) trichloroacetic acid (very strong acid) c) boiling water d) a blender

Biochemistry
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ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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4) Which level of protein structure would be most affected by the following changes...
a) mutation from isoleucine to valine
b) oxidation of two cysteine sidechains
c) PrP° (healthy prion protein, mostly a-helical) changes to PrP* (infectious form, mostly B-strand) (more than
one answer!)
d) increase in pH from 7 to 10
5) Decide on the most likely mode of denaturation for each of the following compounds...
a) hexane (organic solvent)
b) trichloroacetic acid (very strong acid)
c) boiling water
d) a blender
Transcribed Image Text:4) Which level of protein structure would be most affected by the following changes... a) mutation from isoleucine to valine b) oxidation of two cysteine sidechains c) PrP° (healthy prion protein, mostly a-helical) changes to PrP* (infectious form, mostly B-strand) (more than one answer!) d) increase in pH from 7 to 10 5) Decide on the most likely mode of denaturation for each of the following compounds... a) hexane (organic solvent) b) trichloroacetic acid (very strong acid) c) boiling water d) a blender
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