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- 1.) Which of the following would be a good chemotherapy approach: blocking formation of the ribonucleotide GTP or blocking formation of the deoxyribonucleotide dGTP? Why? Please explain the chemical differences between each of the two nucleotides. Use the specific processes below to support your choice by explaining how either GTP or dGTP are related to these and how loss of the particular molecule would affect each process. A.) PEP carboxykinase in gluconeogenesis B.) Succinyl-CoA synthetase in the TCA Cycle C.) Glucagon signal transductionPart A What kind of inhibition is imposed on HIV protease by ritonavir? O irreversible inhibition O reversible inhibition O uncompetitive inhibition. Submit Request Answer1. You are studying a biochemical pathway and isolate Neurospora mutants I, II, and III. Mutant I can grow if you supplement the medium with Z. Mutant Il can grow if you supplement the medium with X, Y, or Z. Mutant III can grow if you supplement the medium with X and Z, but not with Y. Draw a biochemical pathway that shows the correct order for compounds X, Y, and Z and for the enzymes that each mutant is defective for.
- What is the effect of an inhibitor binding an enzyme? The enzyme is degraded. The enzyme is activated. The enzyme is inactivated. The complex is transported out of the cell47. Define group transfer and its role in the cell (Hint: How are amino acids activated by aminoacyl t-RNA synthetase?).Draw the mechanism of action of an HIV protease. Label the substrate, the intermediates, and the products. Indicate each type of catalysis that occurs throughout the mechanism..
- 1. What genetic changes can occur in bacteria to make them resistant to triclosan?2. How could the ability of bacteria to convert saturated fatty acids to unsaturated fatty acids be targeted by antibiotics?3. In a patient with tuberculosis carrying 1012 M. tuberculosis cells, (a) how many bacterial cells are expected to be resistant to isoniazid given a mutation rate of 1 in 108, and (b) how many bacterial cells are expected to be resistant to a combination of three antibiotics, assuming a similar mutation rate?4. Does the ability of cerulenin to stimulate fatty acid oxidation contribute to its antifungal effects?1. a)how is it possible for such drugs to selectively kill bacterial cells and not our own cells? b)Provide an example of post-translational regulation of protein activity and explain the advantage of regulating each protein/process at the post-translational level instead of the transcriptional level.1. Describe which enzymes are required for lactose and tryptophan metabolism inbacteria when lactose and tryptophan, respectively, are (a) present and (b)absent. 2. Contrast positive versus negative regulation of gene expression. Describe therole of the repressor in an inducible system and in a repressible system.
- 1. A variety of organic chelating ligands have been synthesized to tightly coordinate radioactive metal cations to identify and treat malig- nancies by coupling the metal complex to a polypeptide linker attached to a monoclonal antibody that binds specifically to a cell surface re- ceptor. One such metal complex is illustrated in the diagram on the right. The radioactive Cu-64 cation is tightly coordinated by the che- lating ligand that is, in turn, conjugated to a peptide linker attached to a monoclonal antibody. (The antibody is not shown in this diagram.) When coupled to a specifically designed monoclonal antibody, the complex binds specifically to somatostatin receptors that are ex- pressed on the surface of neuroendocrine tumors. Subsequently the entire complex with the receptor is internalized, i.e., passed into the cytoplasm, where the radioactive metal cation kills the malignant cell. CH3 HN NHNH HN NHNH HN НО НО NH HN HN HO S-S NH (a) dues in the polypeptide. Place the label…a. For the E.coli haploid genotype below, determine the phenotype for the following proteins. Assume that any genes or structural elements not shown are wildtype. lacls lacz lacY* lacz [ Select ] lacY [ Select ]), create a simple flowchart depicting the MC1R pathway. There should be a minimum of five steps in the pathway. Be sure to include reception (protein binding to its ligand), a portion of the transduction pathway (what’s the intracellular reaction? What molecule works intracellularly?), and the cellular response (What’s produced from the cell?).
