6. The V, and KM values for an unusual hexokinase found in Try- max pansoma cruzi (the causative agent of Chagas disease) are shown in the presence and absence of a bisphonate inhibitor (structure shown). Without inhibitor With inhibitor Км (mM) 90 125 Vmax (umol · min-1. mL-1) 0.30 0.12 ОН O=P-O- A bisphonate compound a. What type of inhibitor is bisphonate? b. The parasite hexokinase, unlike the mammalian enzyme, is not inhibited by glucose-6-phos- phate but is inhibited by pyrophosphate (PP;). Is this observation con- sistent with your answer to part a? c. Might bisphonate be a good candidate for a drug to treat the disease?
6. The V, and KM values for an unusual hexokinase found in Try- max pansoma cruzi (the causative agent of Chagas disease) are shown in the presence and absence of a bisphonate inhibitor (structure shown). Without inhibitor With inhibitor Км (mM) 90 125 Vmax (umol · min-1. mL-1) 0.30 0.12 ОН O=P-O- A bisphonate compound a. What type of inhibitor is bisphonate? b. The parasite hexokinase, unlike the mammalian enzyme, is not inhibited by glucose-6-phos- phate but is inhibited by pyrophosphate (PP;). Is this observation con- sistent with your answer to part a? c. Might bisphonate be a good candidate for a drug to treat the disease?
Chapter21: Heparin Infusion Calculations
Section: Chapter Questions
Problem 1.3P
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Transcribed Image Text:6. The Vmax and KM values for an unusual hexokinase found in Try-
pansoma cruzi (the causative agent of Chagas disease) are shown in
the presence and absence of a bisphonate inhibitor (structure shown).
Without inhibitor
With inhibitor
Км (mM)
90
125
Vn
max (umol min-1. mL-1)
0.30
0.12
ОН
O=P-O-
A bisphonate compound
a. What type of inhibitor is bisphonate? b. The parasite hexokinase,
unlike the mammalian enzyme, is not inhibited by glucose-6-phos-
phate but is inhibited by pyrophosphate (PP;). Is this observation con-
sistent with your answer to part a? c. Might bisphonate be a good
candidate for a drug to treat the disease?
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