71. An investigator studying hormonal dysfunction creates a line of experimental animals. The pregnant experimental animals from this line show no significant uterine contractions at the standard parturition time. They also exhibit signs of diabetes insipidus. Hypothalamic immunocytochemistry indicates that the experimental animals produce normal amounts of oxytocin and ADH (vasopressin). Which of the following is the most likely cause of the hormonal dysfunction in these experimental animals? A) Blockage of neurosecretory cell axonal transport B) Blockage of the hypophyseal portal system C) Destruction of paraventricular nuclei D) Excess of neurophysin in the hypothalamic neurosecretory cells OE) Excess of somatostatin in the hypothalamus

Essentials of Pharmacology for Health Professions
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Chapter24: Reproductive System Drug
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71. An investigator studying hormonal dysfunction creates a line of experimental animals. The pregnant experimental animals from this line show no significant uterine contractions at the
standard parturition time. They also exhibit signs of diabetes insipidus. Hypothalamic immunocytochemistry indicates that the experimental animals produce normal amounts of oxytocin and
ADH (vasopressin). Which of the following is the most likely cause of the hormonal dysfunction in these experimental animals?
A) Blockage of neurosecretory cell axonal transport
B) Blockage of the hypophyseal portal system
C) Destruction of paraventricular nuclei
D) Excess of neurophysin in the hypothalamic neurosecretory cells
E) Excess of somatostatin in the hypothalamus
Transcribed Image Text:71. An investigator studying hormonal dysfunction creates a line of experimental animals. The pregnant experimental animals from this line show no significant uterine contractions at the standard parturition time. They also exhibit signs of diabetes insipidus. Hypothalamic immunocytochemistry indicates that the experimental animals produce normal amounts of oxytocin and ADH (vasopressin). Which of the following is the most likely cause of the hormonal dysfunction in these experimental animals? A) Blockage of neurosecretory cell axonal transport B) Blockage of the hypophyseal portal system C) Destruction of paraventricular nuclei D) Excess of neurophysin in the hypothalamic neurosecretory cells E) Excess of somatostatin in the hypothalamus
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