A 28-year-old man experiences prolonged apnea following the administration of succinylcholine for tracheal intubation. A hereditary deficiency of which of the following enzymes is most likely responsible for this condition? Answers A - E A Acetylcholinesterase B Butyrylcholinesterase C Cytochrome P4503A D Glucose-6-phosphate dehydrogenase E Monoamine oxidase O O O O
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- asapIndividuals with the disease alkaptonuria fail to produce the enzyme homogentisic acid ? in their liver. permease meriase oxidase tyrosinase hydroxylasePlease answer the following questions 1. Give the substrate for each of the following enzymes: a. dihydrofolate reductase b. acetylcholinesterase c. lactate dehydrogenase d. DNA polymerase e. aspartate transaminase
- You have a crude lysate sample (CL) containing a mixture of six proteins (1, 2, 3, 4, 5, ẞ- galactosidase), and your goal is to obtain purified ẞ-gal. Some characteristics of these proteins are shown in the table below. Protein Alcohol dehydrogenase Carbonic anhydrase Insulin B chain Phosphorylase B Glutamic dehydrogenase B-galactosidase 45% Concentration of ammonium sulfate (AS) required for precipitation Molecular Weight (kDa) Isoelectric point (pl) 38 3.7 80% 65% 20% 30% 45% 28 4.8 4 5.3 98 6.8 49 9.5 115 5.3 You begin your purification by performing an ammonium sulfate (AS) precipitation. You add the appropriate concentration of AS to your CL sample, incubate overnight at 4°C, then centrifuge to generate a supernatant (AS-S) and pellet (AS-P). What concentration of AS will you use to precipitate Glutamic dehydrogenase? © 20% O 30% 45% 65% 80%One treatment for hyperuricemia is administration of xanthine oxidase inhibitors like allopurinol. Discuss the mechanism and show an illustration how this drug able to alleviate symptoms of hyperuricemia.Answer the following questions: 1. A patient suffering from fatigue and pallor has been diagnosed of megaloblastic anemia and was given vitamin B12 (cobalamin) as a supplement. Megaloblastic anemia occurs due to reduced activity of methionine synthase, an enzyme responsible for the conversion of homocysteine to methionine. What role is played by vitamin B12 (cobalamin) to methionine synthase? A. apoenzyme B. coenzyme C. holoenzyme D. isoenzymes E. cofactor 2. A given substrate may be acted upon by a number of different enzymes, each of which uses the same substrate(s) and produces the same product(s). The individual numbers of a set of enzymes sharing such characteristics are known as ___, which are of clinical interest because they can be used as molecular markers of tissue damage. A. Cofactor B. Coenzyme C. Holoenzyme D. Apoenzyme E. Isoenzymes 3. Succinic acid dehydrogenase is an enzyme which catalyzes the oxidation of succinic acid during cell respiration. If malonic acid is…
- Panthothenic acid is involved in the metabolic pathways as coenzyme:Which of the following Krebs cycle enzymes generates a molecule of FADH2 from FAD? a-ketoglutarate dehydrogenase pyruvate dehydrogenase isocitrate dehydrogenase malate dehydrogenase succinate dehydrogenaseDefine the following terms:a. cytochrome P450b. mixed-function oxidasec. flavin-containing monooxygenased. detoxicatione. detoxification
- Which of these enzymes is needed to maintain a steady pool of methylene THF used in pyrimidine synthesis and cancer cells proliferation? Group of answer choices Phosphoglyceratedehydrogenase Glyceraldehydegehydrogenase Glycine decarboxylase ThymidylatesynthaseSuccinate dehydrogenase is a/an Select the correct response: Oxidoreductase isomerase hydrolase transferase lyase ligaseThe name of the enzyme that catalyzes the conversion of ATP to CAMP is: CAMP synthase Adenylyl cyclase Phosphodiesterase Pyrophosphate OO 00