A 49-year-old woman presents to her physician with concerns about her recent unintended weight loss and oral lesions that have made chewing painful. The lesions have persisted for the past three months. Physical examination confirms lesions on her oral mucosa and reveals flaccid bullae with eruptions on her trunk. Lateral pressure applied to the border of a bilister causes the blister to spread. Serological studies are most likely to show autoantibodies directed against which of the following proteins? Answers E A BPAG2 B Desmoglein C Integrin D Keratin E Reticulin
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- What is the correct diagnosis of the disease and the causative agent(s). A 28 year old male presented to the emergency deaprtment with a 1 day history of sore throat and fever. Upon physical examination, there was tonsillar swelling noted without the prescence of pus. A throat swab was conducted and a rapid antigen detection test for Group A Streptococcus (GAS) was performed in the ED. Results were negative. A throat swab for the culture was also collected. The patient was sent home with a diagnosis of presumed viral pharyngitis. The next day, the patient returned to the ED with worsening sore throat and difficulty swallowing. Pus was seen on the tonsils and the uvula was deviated towars one sight of his throat. Viral Agents. Bacteria Rhinovirus Group A streptococcus Adenovirus Group C Streptococcus Coronavirus G SStreptococcus…Jonathan Miller, aged 6 years, was brought to emergency room by his parents; he was presenting with fever, severe headache, a petechial rash, stiff neck and vomiting. Jonathan had a history of recurrent sinusitis and otitis media, all caused by pyogenic bacteria and treated successfully with antibiotics. Suspecting bacterial meningitis, the attending physician began an immediate course of intravenous antibiotics and requested a lumbar puncture. Neisseria meningitidis was grown from the cerebrospinal fluid. The physician was concerned about the recurrence of infections caused by pyogenic bacteria, and he suspected an immunodeficiency. He ordered blood tests and found the serum complement profiles to have low C3, factor B, and factor H, and undetectable factor I. Which of the following explains why a factor I deficiency is associated with infections caused by pyogenic bacteria? a. Elevated levels of C3 convertase C3bBb interfere with the activation of the classical pathway of…A 31-year-old man presented with slowly spreading hyperpigmented and crusted lesions with the largest measuring 3 cm x 4 cm. The lesion started from the right sole of the foot and spread diffusely through the left ankle. He did not have similar lesions in the past, and there is no significant history of any chronic illness in the past. Upon examining his skin biopsy samples, the histopathological examination results showed: a. Pseudoepitheliomatous epidermal hyperplasia with the presence of pigmented spores arranged singly and in chains with peripheral neutrophil infiltration.b. Ziehl- Neelson staning negativec. PAS positived. Pus and granules negativee. Presence of granulomas along with golden- brown, thick- walled, spherical bodies about 5 to 8 μm in size. Questions: What disease can you infer from the results that are shown? Why have you said so? The case presented can be mistaken for what skin cancer? Why? What treatment is best to be given? What protective measures can be done to…
- Kindly answer the case study below:Diagnosis: Bacterial vaginosis Case Study:A 24-year-old woman notes vaginal itching and irritation with a slight discharge. Previously, she developed a yeast infection that was treated with over-the-counter medications and resolved. Thinking that this was a recurrence, she again self-treated. This time, however, the symptoms did not resolve, and now there is a pungent odor, along with a frothy discharge. She presents to her HMO for diagnosis, and the nurse practitioner takes a swab of the secretions to perform a rapid point-of-care test and microscopy. A wet mount of the swab demonstrates swimming protozoan with characteristic jerky motility. A stained smear also showed pear-shaped trophozoite with flagella.Case study presentation should include the following:1. Case2. Patient initials (Ex. 50-year-old man)3. History of the present illness (Symptoms and may include the physical exam of the patient)4. Chief Complaints (Ex. Morning stiffness in his…22-year-old woman has had recurrent episodes of diarrhea, crampy abdominal pain, and slight fever over the last 2 years. At first the episodes, which usually last 1 or 2 weeks, were several months apart, but recently they have occurred more frequently. Other symptoms have included mild joint pain and sometimes red skin lesions. On at least one occasion, her stool has been guaiac-positive, indicating the presence of occult blood. Colonoscopy reveals several sharply delineated areas with thickening of the bowel wall and mucosal ulceration. Areas adjacent to these lesions appear normal. Biopsies of the affected areas show full-thickness inflammation of the bowel wall and several noncaseating granulomas. 1. What is the most likely diagnosis? 2. What are the common complications of this disease?A 44-year-old Nigerian man was admitted as an emergency while visiting relatives in England. His symptoms include abdominal pain, sweating, rigors and vomiting. Had been treated twice for malaria but had never taken malarial prophylaxis. Examination revealed he is ill and jaundiced, temperature of 39.2°C, blood pressure was 90/70, but no signs of visceral perforation. Differential diagnosis include– occult gastrointestinal bleeding, septicaemia, hepatitis or recurrence of malaria Emergency investigations: normal haemoglobin (140g/l), white cell count of 6.1 x 109/l, sickle-cell anaemia (excluded), thick blood film Treatment: intravenous quinine. Unfortunately the Px rapidly deteriorated over the next 30h leading to cardiac arrest. Post-mortem diagnosis: Cerebral Malaria QUESTION: 1.What is your final diagnosis here? Explain the cause of his disease. 2. What drug, dosage form, schedule, and duration of therapy are best for treating patients with this condition?
- A 17-year-old boy presents to his pediatrician for evaluation of a rash in his genital area. He reports that it is very itchy and started about 1 week ago. At school, he participates in multiple sports, including wrestling with practice 3 times a week. He admits that he does not always wash his hands and often delays showering after practice. Physical examination reveals a red, scaly rash as shown in the attached image. Which of the following is the most likely cause of the rash? Answers A - E A Eikenella corrodens B Malassezia furfur C Mycobacterium marinum D Sporothrix schenckii E Trichophyton rubrum O O Question #22 attachment oA 17-year-old boy presents to his pediatrician for evaluation of a rash in his genital area. He reports that it is very itchy and started about 1 week ago. At school, he participates in multiple sports, including wrestling with practice 3 times a week. He admits that he does not always wash his hands and often delays showering after practice. Physical examination reveals a red, scaly rash as shown in the attached image. Which of the following is the most likely cause of the rash? Answers A - E A Eikenella corrodens B Malassezia furfur C Mycobacterium marinum D Sporothrix schenckii E Trichophyton rubrum O O O OMrs Okello, 24 years old is brought to your health center with history of bloody mucoid stool, fever, vommiting and abdominal cramps.She resides near crude damping site (open waste disposal site) and looks malnourished and weak. (Assume she is so weal and she will be admitted)(a)What is the probable diagnosis of Mrs Okello.(b)Name the causative organism of Mrs Okello’s illness.(c)What factors could have influenced the acquisition or recurrence of this disease.(d)Describe the management of Mrs Okello at the health center.(e)What are the possible complications of this condition.2.Amoebiasis (infection with amoeba) is among the ten top conditions treated at many rural health facilities.(a)Give the pathogenic ……. that cause amoebiasis.(b)By use of a diagram illustrate the transmission life cycle of amoeba.((c)State five clinical features of a patient with amoebiasis(d)Briefly explain six general prevention and controls of amoebiasis
- Mr. Jones is a 69-year-old man who was admitted to the hospital 10 days earlier with a diagnosis of acute diverticulitis. He was given intravenous fluids and empiric antibiotic coverage with ceftriaxone and metronidazole. His antibiotics were stopped after 7 days, and he continued to do well until today, when he developed abdominal pain, fever, and diarrhea. A diagnosis of Clostridium difficile colitis was made, and antibiotic treatment was initiated. Discuss the following questions: What diagnostic test would confirm the diagnosis? What risk factors did Mr. Jones have to acquire a Clostridium difficile infection? Why is oral but not intravenous vancomycin a potential treatment option for this infection? One person from each group should respond to this discussion with a link to their group’s recording and a summary of the discussion that took place.A 63-year-old woman presented with increasing darkening of the skin, dizziness, and easy fatigability, nausea with occasional vomiting and progressive weight loss over eight months prior to presentation. There were no headaches, blurred vision, and neither loss of consciousness nor change in her bowel habit. The medical history and systemic review revealed no abnormality and were not significant as to the likely cause of her disease state. Physical examination revealed an elderly lady, pale, asthenic with generalized hyperpigmentation especially on the face, oral mucosa, palmar creases and knuckles. No features of malnutrition or hypovitaminosis. There was no significant peripheral lymphadenopathy. Main findings in the systemic examination were a pulse of 106 bpm, regular and small; blood pressure 100/60 mmHg supine and 70/40mmHg sitting. She could not stand on account of severe postural dizziness. The apex beat was normal. Fundoscopy revealed a normal fundus. All other systems were…Patient X was rushed to a nearby hospital in Tuguegarao City after experiencing severe abdominal pain, persistent vomiting, marked change in temperature going from fever to hypothermia, restlessness, cold, clammy skin, and rapid, weak pulse. In addition, Patient X noted that she experienced high bouts of fever during the first week but has subsided. Small red spots or purple splotches can be seen on her skin, and she tested positive on the tourniquet test. According to her travel history, she recently visited Aklan and Negros Occidental Answer the following questions:4. Which of her symptoms indicate early signs of shock? Which of her symptoms point to hemorrhagic manifestations?5. Enumerate laboratory methods that can be used to diagnose the disease or detect the virus.6. How is the disease treated and controlled/prevented?