A cancerous tumour is exposed to an Q-emitter with an RBE of 12. What absorbec dose, in Gy, is needed to give the tumour an effective dose of 60 Sv? Report your final answer rounded to two significant digits.
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- Mrs B presents you with a prescription for warfarin tablets 1 mg. The directions are to take 6 mg at 6pm that evening, followed by alternating daily doses of 4 mg and then 3 mg (as long as her INR remains within the recommended range). What is the exact number of warfarin 1 mg tablets required for a 28 day supply assuming her INR remains in range?Acute lymphatic leukemia can respond well to methotrexate given 2.5 mg/kg every 14 days by IV. What would be the appropriate dosage of methotrexate to administer biweekly to a patient weighing 110 pounds?Mrs B, aged 43 years, weight 56 kg, requires a loading dose of drug B. The target plasma concentration is 18.9 mg/ L, volume of distribution is 0.5 L/ kg, the salt factor is 0.9 and bioavailability fraction is 1. What is the intravenous loading dose (LD) of Drug B in milligrams (mg)? units - mg LD = Cp desired x Vd S x F Where Cp desired is the target plasma concentration; Vd is the volume of distribution; S is the salt factor and F is the bioavailability fraction
- Is 40mg PO BID a safe dose explain your answer.Assume that Ali (same patient in question 1) was prescribed vancomycin 1000 mg every 36 hours. After few days, Steady-state vancomycin concentrations were obtained before and after the fourth dose, and the peak concentration (obtained ½ hour after a 1- hour infusion of vancomycin) was 34 µg/mL while the trough concentration (obtained immediately before dosage administration) was 2.5 pg/mL. Compute a revised vancomycin dose for this patient to provide a steady-state peak concentration of 48 ug/mL and a steady- state trough concentration of 17 pg/mL. a. Estimate new rate constant (Ke) and half-life (t1/2) b. Estimate volume of distribution (Vd) using this equation Cmaxss + Cminss C. Calculate the new dose interval d. Calculate the new dose Mr. Yeboah, diagnosed with a malignant tumour of the liver had it removed and was given a course of chemotherapy. Initially, tumour marker (AFP) activity activity was 7500KU/L (which is very high) but after treatment, this gradually declined to only 5KU/L. A routine follow up test was perfomedafter 3 months and the results was 15KU/L for AFP. The doctor suspected a relapse of the tumour and so referred Mr. Yeboahto an oncologist at a cancer centre who also did a re-check. AFP was recorded to be 5KU/L. Enquiries revealed that the hospital and the cancer centre use different instruments for the measurement of AFP. Both results are normal even though the values are significantly different because different methods were used.a) How can both labs confirm that the results are not clinically significant? b) How can both labs avoid this happening again?
- A 158lb adult male diagnosed with endocarditis has an order for gentamicin 3mg/kg/day IV in 2 divided doses, in addition to vancomycin. The Gentamicin is available in 2 mL vials containing 40mg/mL. The facility protocol is to round the gentamicin dose to the nearest 10mg, then calculate the volume of solution to the nearest tenth mL. How many mL will administer per dose?The nurse is preparing to give Acetaminophen to a 5year old girl weighing 20 kg. The doctor has ordered Acetaminophen 240mg PO qehr PRN pain. the safe dose range for acetaminophen is 10-15 MG/KG/dose. What is the low safe amount per dose? [1] What is the high safe amount per dose? (2) is this dose safe to give? (3]A prescription order calls for 1.25 g of vancomycin in 500 mL of NS (0.9%/100mL). After reconstitution vancomycin injection is available in a strength of 50 mg/mL. How many mL of vancomycin injection should be drawn up to prepare this prescription?
- A single dose of 300mg of drug is 63% bioavailable by the IM route. The same drug is 42% bioavailable by the oral route. How many 150mg tablets would need to be administered PO BID to achieve plasma levels comparable to the IM dose?A cat presents with suspected acute, severe sepsis. The veterinarian asks you to draw up a dose of IV gentamicin. The dosage for a cat with acute sepsis is 2.2 mg/kg. Calculate the dose for an 8-lb cat. The concentration of gentamicin is 50 mg/ml. Show me your calculation Please note that: 1Kg= 2.2 lbAspirin is considered as an acidic drug given at a dose of 80 mg tablet as an antithrombotic agent for patients with angina and prevention of myocardial and cerebral infarction. In today’s market, some preparations of aspirin would be given as 100 mg enteric coated tablet. Why is the enteric coated tablet given in 100 mg dose as compared to the compressed tab of 80 mg only?
