A mutation of Drosophila has a wing condition known as beaded. When a beaded fly was crossed with a pure-line normal fly, 53 beaded and 47 normal F1 's were produced. When two of the F, beaded flies were mated, 67 beaded and 33 normal F2's were produced. Explain the genetics of the beaded trait and give the genotypes of all P and F1 generation flies.
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- In Drosophila, a cross (cross 1) was made between twomutant flies, one homozygous for the recessive mutationbent wing (b) and the other homozygous for the recessivemutation eyeless (e). The mutations e and b are alleles oftwo different genes that are known to be very closelylinked on the tiny autosomal chromosome 4. All the progeny had a wild-type phenotype. One of the female progeny was crossed with a male of genotype b e/b e ; we willcall this cross 2. Most of the progeny of cross 2 were of theexpected types, but there was also one rare female ofwild-type phenotype.a. Explain what the common progeny are expected tobe from cross 2.b. Could the rare wild-type female have arisen by (1)crossing over or (2) nondisjunction? Explain.In a vial of Drosophila, a research student noticedseveral female flies (but no male flies) with bag wingseach consisting of a large, liquid-filled blister insteadof the usual smooth wing blade. When bag-wingedfemales were crossed with wild-type males, 1/3 of theprogeny were bag-winged females, 1/3 were normalwinged females, and 1/3 were normal-winged males.Explain these results.In Drosophila, a cross was made between females expressing thethree X-linked recessive traits, scute bristles (sc), sable body (s),and vermilion eyes (v), and wild-type males. All females were wildtype in the F1, while all males expressed all three mutant traits.The cross was carried to the F2 generation and 1000 offspringwere counted, with the results shown in the following table. Nodetermination of sex was made in the F2 data. Question:Calculate the coefficient of coincidence; does this represent positive or negative interference? Phenotype Offspringsc s v 314+ + + 280+ s v 150sc + + 156sc + v 46+ s + 30sc s + 10+ + v 14
- In Drosophila, the gene loci for curved wings and purple eyes are 20 centimorgans (map units) apart from each other on an autosomal chromosome. Wild-type flies were mated with double mutant flies with cv cv p p genotypes and curved wing/purple eye phenotypes. AlIl of the F1 flies had wild type phenotypes. The F, flies were crossed with double mutant flies with cv cv p'p genotypes and curved wing/purple eye phenotypes. What are the predicted percentages of flies in the F2 generation with wild type wings and eyes, curved wings and wild type eyes, wild type wings and purple eyes, and curved wings and purple eyes?In Drosophila, a heterozygous female for the X-linkedrecessive traits a, b, and c was crossed to a male that phenotypically expressed a, b, and c. The offspring occurred inthe following phenotypic ratios.+ b c 460a + + 450a b c 32+ + + 38a + c 11+ b + 9 No other phenotypes were observed.(a) What is the genotypic arrangement of the alleles ofthese genes on the X chromosome of the female?When Thomas Hunt Morgan crossed his red-eyed F1 generation flies to each other, the F2 generation includedboth red- and white-eyed flies. Remarkably, all the white-eyed flies were male. What was the explanation forthis result? a. The gene involved is on the X chromosomeb. The gene involved is on the Y chromosomec. The gene involved is on an autosome, but only in malesd. Other male-specific factors influence eye color in fruit fliese. None of these is correct
- In Drosophila, a heterozygous female for the X-linkedrecessive traits a, b, and c was crossed to a male that phenotypically expressed a, b, and c. The offspring occurred inthe following phenotypic ratios.+ b c 460a + + 450a b c 32+ + + 38a + c 11+ b + 9 No other phenotypes were observed.(a) Determine the correct sequence and construct amap of these genes on the X chromosome ?In Drosophila, the vestigial wings recessive allele,vg, causes the wings to be very small. A geneticistcrossed some true-breeding wild-type males to some vestigial virgin females. The male and female F1 flieswere wild type. He then allowed the F1 flies to matewith one another and found that 1/4 of the male andfemale F2 flies had vestigial wings. He dumped thevestigial F2 flies into a morgue and allowed the wildtype F2 flies to mate and produce an F3 generation.a. Give the genotype and allele frequencies amongthe wild-type F2 flies.b. What will be the frequencies of wild-type andvestigial flies in the F3?c. Assuming the geneticist repeated the selection againstthe vestigial F3 flies (that is, he dumped them in amorgue and allowed the wild-type F3 flies to mate atrandom), what will be the frequency of the wild-typeand mutant alleles in the F4 generation?d. Now the geneticist lets all of the F4 flies mate atrandom (that is, both wild-type and vestigial fliesmate). What will be the…Drosophila P elements were discovered because ofa phenomenon called hybrid dysgenesis—sterilityof particular hybrid progeny. When scientists in the1970s crossed their D. melanogaster laboratorystrains to flies of the same species obtained fromnatural environments outside the lab, they observeda remarkable result: The progeny of the crosseswere sterile, but only when outside males werecrossed with lab strain females. Progeny resultingfrom crosses of outside females with lab maleswere perfectly normal.DNA analysis revealed that while the genomesof the outside flies contain P elements, the lab flygenomes have none. Apparently, P elements spreadthroughout the wild population of D. melanogasterafter the capture of the originators of present-daylaboratory strains over 100 years ago.a. The hybrid progeny are sterile because their germline cells have a high rate of mutation and chromosomal rearrangement (dysgenesis) caused by highrates of P element mobilization. Explain howP element movement…
- When Calvin Bridges observed a large number of offspring from a cross of white-eyed female Drosophila tored-eyed males, he found very rare white-eyed femalesand red-eyed males among the offspring. He was ableto show that these exceptions resulted from nondisjunction, such that the white-eyed females had received twoXs from the egg and a Y from the sperm, while thered-eyed males had received no sex chromosome fromthe egg and an X from the sperm. What progeny wouldhave arisen from these same kinds of nondisjunctionalevents if they had occurred in the male parent? Whatwould their eye colors have been?In Drosophila, males from a true-breeding stock withraspberry-colored eyes were mated to females from atrue-breeding stock with sable-colored bodies. In theF1 generation, all the females had wild-type eye andbody color, while all the males had wild-type eyecolor but sable-colored bodies. When F1 males andfemales were mated, the F2 generation was composedof 216 females with wild-type eyes and bodies, 223females with wild-type eyes and sable bodies, 191males with wild-type eyes and sable bodies, 188 maleswith raspberry eyes and wild-type bodies, 23 maleswith wild-type eyes and bodies, and 27 males withraspberry eyes and sable bodies. Explain these resultsby diagramming the crosses and calculating any relevant map distancesA Drosophila embryo dies during early embryogenesis due to arecessive maternal effect allele called bicoid−. The wild-type alleleis designated bicoid+. What are the genotypes and phenotypes ofthe embryo’s mother and maternal grandparents?