• Ovarian cancer has an incidence rate of o.2% in thenormal female population. A new tumour marker assay,called Q, used in detecting ovarian cancer has beendeveloped. A clinical trial was performed involving100,000 females and the effectiveness of the assay wasassessed. The results are given in the table below:Disease presentYesNoPositive test196 (TP)6986 (FP)1......Negative test4 (FN)92814 (TN)a) What is the PPV of the assay?b) What is the NPV of the assay?c) Comment on your findings

There are two parameters that help us determine the performance of a certain diagnostic test or…

Answered: a) What is the PPV of the assay? b)…

Science

Biology

a) What is the PPV of the assay? b) What is the NPV of the assay? c) Comment on your findings

Biology 2e

2nd Edition

ISBN:9781947172517

Author:Matthew Douglas, Jung Choi, Mary Ann Clark

Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark

Chapter17: Biotechnology And Genomics

Section: Chapter Questions

Problem 3VCQ: Figure 17.15 In 2011, the United States Preventative Services Task Force recommended against using...

See similar textbooks

Similar questions

35) A study is conducted to evaluate the overall impact of prostate-specific antigen testing as a screening tool for prostate cancer in otherwise investigators have data on rates of cancer and all-cause mortality and prostate cancer-specific mortality. An analysis of mortality (including impotence and urinary incontinence), and the psychological impact of screening (including anxiety and sleeplessness) is of utilities associated with these outcomes, and the investigators use the data to determine the probabilities associated with the various best outcome measures to use in this study? Case-specific mortality Quality-adjusted life years Risk-adjusted mortality Standardized mortality ratio Years of potential life lost
22:23 1O 000 · 11:24 A9 OB1 r ll l 52% . +964 782 734 3923 2m541139927815107... Patient Encounter Part 3 The pretreatment workup is summarized below. Pathology: 47-year-old female with new diagnosis of infiltrating intraductal adenocarcinoma involving the left breast and regional node. Further tests on tumor samples indicated ER (8%), PR (negative), HER2 (negative), Ki-67 (72%), and grade (poorly differentiated). Intrinsic subtype (luminal B, HER2-negative). Radiology: FDG-PET/CT indicated a 5.3 x 2.5 cm mass in the left breast which appeared to extend to the epidermis of the skin; one node in the left axilla was also involved with tumor. No other evidence of distant disease was visualized. Laboratory: CBC, liver, and kidney function tests WNL, alkaline phosphatase and calcium are normal also. Stage: IB (T, N, M,) List the most important prognostic factors in this patient with newly diagnosed breast cancer. Assess the patient's level of risk for relapse. 50 SECTION 16 | ONCOLOGIC…
1. What is Du? ANSWERS TO QUESTIONS ON LABORATORY ASSAY NO.7 2. Why do we need test for Du when weak or no reaction is obtained in Rh typing? 3. What is required to demonstrate the presence of cells carrying a weak D antigen? 4. Explain the mechanism behind the existence of Du. 5. Cite possible situations in which an attending physician would request for an emergency screening for the presence of "D" antigen.
A standard course of post-operational gamma or x-ray therapy, normally given after operations to remove breast cancer, consists of daily fractions of 1.7 Gy,5 days a week for 6 weeks. Estimate the risk of inducing new breast from this treatment.
Breast Cancer Screening Program – A group of women were subjected to a breast cancer screening program. A newly developed screening test was utilized to measure its sensitivity and specificity against a gold standard test. a) What is the prevalence of breast cancer in this population? b) Calculate the Sensitivity of the test and provide interpretation c) Calculate the Specificity of the test and provide interpretation
“The overall absolute increase in breast cancers diagnosed among current and recent users of any hormonal contraceptives was 13 (95% CI, 10 to 16) per 100,000 person-years, or approximately 1 extra breast cancer for every 7690 women using hormonal contraception for 1 year”. What is the term used in epidemiology which describes this sentence? Please calculate this number and comment on its magnitude.
8-6. Identifying Study Subjects A study entitled “Antidepressant Medication and Breast Cancer Risk” (Amer. J. of Epi, late 1990’s) stated in the methods section of the paper that “Cases were an age-stratified (< 50 and ≥ 50 years of age) random sample of women aged 25-74 years diagnosed with primary breast cancer during 1995 and 1996 (pathology report confirmed) and recorded in the population-based Ontario Cancer Registry. As the 1-year survival for breast cancer is 90%, surrogate respondents were not used. Population controls, aged 25-74 years, were randomly sampled from the property assessment rolls of the Ontario Ministry of Finance; this database includes all home owners and tenants and lists age, sex, and address.” Discuss the authors’ approach to the identification of cases with respect to the potential for selection bias. Discuss the authors’ approach to the identification of controls with respect to the potential for selection bias. Does the decision not to allow surrogate…
You are evaluating apatient with a cancer type that is characterized by constitutive expression of NFϏB - which promotes oncogenesis, Bortezomib will be most effective in managing the patient. Group of answer choices True False
5. The MLT performs patient testing against specific reagent anti-sera and obtains the following results: Anti-e Anti-D 4+ Anti-c 3+ 3+ Anti-C 3+ a) What is this patient's Rh phenotype? Anti-E 0
The remains of nine human beings were found in a site, degree of bone development and presence of Y chromosome DNA suggest four adult females (A, B, C & D), two adult males (E, F) and three juvenile females. Their DNA was available for testing. The gel pattern obtained for one SSR probe is shown in the figure below. The bands are numbered in order of increasing electrophoretic mobility. Adult O Adult O Juvenile Y A B C D E F G H I 1 -2 3. 9. 8. 10 Which of the following can you conclude from the results? Select all that apply Female C could be the biological parent of the three juvenile females OMale F could be the biological parent of the three juvenile females Female D could be the biological parent of the three juvenile females Male E could be the biological parent of the three juvenile females
In a Cervical Cancer screening program, 500 asymptomatic women were examined using the Pap smear test. 200 of the women who truly had lesions were correctly classified; 14 with lesions were wrongly classified as negative. 253 women who had no lesions were correctly classified; 33 women with no lesions were wrongly reported as positive. (A) Summarise the information provided in an appropirate table. (B) Based on the information above, calculate the Sensitivity, Specificity, Positive and Negative Predictive Values of the Pap smear test.
There are 2 main ways of treating tumours - external irradiation by radiotherapy and internal radiopharmaceuticals. Using the points shown below, explain the advantages and disadvantages of using radiopharmaceuticals as opposed to external irradiation. • Area of treatment required • Position of tumour • lonising range • Precautions needed after treatment