A. The structural characteristics of the CTXA3 protein that allow it to interact with a membrane. B. Why it would preferentially interact with phosphatidylserine-rich membranes. C. How this interaction would cause leakage from the membrane.

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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A. The structural characteristics of the CTXA3 protein that allow it to interact with a membrane. B. Why it would preferentially interact with phosphatidylserine-rich membranes. C. How this interaction would cause leakage from the membrane.
Score
B
6-CF leakage (%)
30-
20-
10-
0.6
0.4
A
0.2
0
-0.2
-0.4
-0.6
-0.8
-1
-1.2
0
40
80
Time (second)
10
L1 82
10
20
83
20
120
30
-100% PS vesicle + CTXA3
-50% PS:PC vesicle + CTXA3
-100% PC vesicle + CTXA3
-100% PS vesicle + CTXA5
Transmembrane tendency
L2
PS = phosphatidylserine
PC = phosphatidylcholine
40
40
50
L3 B5
30
CTXA3: LKCNKL-VPLEYKTCPAGKNLCYKMFMVATP-KVPVKRGCIDVCPESSLIVKYVCONTDRCN: 60
CTXA5: LKCHNTQLPFIYKTCPEGKNLCFKATLKKFPLKFPVKRGCADNCPKNSALLKYVCCSTDKCN : 62
50
Arrows = positively charged residues
60
60
Transcribed Image Text:Score B 6-CF leakage (%) 30- 20- 10- 0.6 0.4 A 0.2 0 -0.2 -0.4 -0.6 -0.8 -1 -1.2 0 40 80 Time (second) 10 L1 82 10 20 83 20 120 30 -100% PS vesicle + CTXA3 -50% PS:PC vesicle + CTXA3 -100% PC vesicle + CTXA3 -100% PS vesicle + CTXA5 Transmembrane tendency L2 PS = phosphatidylserine PC = phosphatidylcholine 40 40 50 L3 B5 30 CTXA3: LKCNKL-VPLEYKTCPAGKNLCYKMFMVATP-KVPVKRGCIDVCPESSLIVKYVCONTDRCN: 60 CTXA5: LKCHNTQLPFIYKTCPEGKNLCFKATLKKFPLKFPVKRGCADNCPKNSALLKYVCCSTDKCN : 62 50 Arrows = positively charged residues 60 60
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