After oral administration of single 100 mg capsule of an antihypertensive drug to a normal volunteer, the total calculated AUC was 20 mg.hr/L. After intravenous bolus administration of 20 mg, the AUC was 10 mg.hr/L. Calculate the absolute bioavailability of the drug from the tablet applied orally. (10. SLAYT) A) 60% B) 20% C) 40% D) 50% E) 75% What sould be the minimum solubility of an active substance (its molecular weight:500) in the dissolution media to be chosen in order to ensure the sink condition in the paddle method by using a 1 liter volume of beaker of a tablet (its dose strength is 100 mg and tablet weight is 200 mg? (4. SLAYT) 1 mg/ml 200 mg/ml 20 mg/ml 5 mg/ ml 10 mg/ ml
After oral administration of single 100 mg capsule of an antihypertensive drug to a normal volunteer, the total calculated AUC was 20 mg.hr/L. After intravenous bolus administration of 20 mg, the AUC was 10 mg.hr/L. Calculate the absolute bioavailability of the drug from the tablet applied orally. (10. SLAYT) A) 60% B) 20% C) 40% D) 50% E) 75% What sould be the minimum solubility of an active substance (its molecular weight:500) in the dissolution media to be chosen in order to ensure the sink condition in the paddle method by using a 1 liter volume of beaker of a tablet (its dose strength is 100 mg and tablet weight is 200 mg? (4. SLAYT) 1 mg/ml 200 mg/ml 20 mg/ml 5 mg/ ml 10 mg/ ml
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- After oral administration of single 100 mg capsule of an antihypertensive drug to a normal volunteer, the total calculated AUC was 20 mg.hr/L. After intravenous bolus administration of 20 mg, the AUC was 10 mg.hr/L. Calculate the absolute bioavailability of the drug from the tablet applied orally. (10. SLAYT)
- A) 60%
- B) 20%
- C) 40%
- D) 50%
- E) 75%
- What sould be the minimum solubility of an active substance (its molecular weight:500) in the dissolution media to be chosen in order to ensure the sink condition in the paddle method by using a 1 liter volume of beaker of a tablet (its dose strength is 100 mg and tablet weight is 200 mg? (4. SLAYT)
- 1 mg/ml
- 200 mg/ml
- 20 mg/ml
- 5 mg/ ml
- 10 mg/ ml
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