Cell wall inhibitors – (including Penicillins) - Inhibitors of protein synthesis Injury to plasma membrane Nucleic acid synthesis inhibitors Inhibit metabolite synthesis
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Understand the common bacterial targets for bacterial infections and why they make good targets:
- Cell wall inhibitors – (including Penicillins) -
- Inhibitors of protein synthesis
- Injury to plasma membrane
Nucleic acid synthesis inhibitors- Inhibit metabolite synthesis
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- Give two examples of antibiotics that act on the following: cell wall synthesis disruption of cell membrane interferes protein synthesis prevents DNA/RNA replication Disruption of formation of metabolites like Folic AcidA pathogenic bacteria ferments for survival in your patient producing a swollen, dark discolored leg due to muscles degradation and gas-filled distension on the skin. Treatment includes pressurized hyperbaric oxygen. Which of the following apply? None of the statements apply Streptococcus pneumoniae causing community aquired pneumonia. Klebsiella pneumoniae causing cellular degradation in pulmonary tissues Clostridium perfringens causing gas gangrene resulting in myonecrosis by synthesis of acids and gases Staphylococcus aureus producing lipases and proteasesSome bacteria produce the enzyme penicillinase, which breaks the beta-lactam ring in the penicillin molecule and converts it into penicilloic acid, which is harmless to bacteria. This is an example of which of the following mechanisms of antibiotic resistance? which option below is the answer? Destruction or inactivation of the antibiotic by the microbe Preventing penetration to the target site within the microbe Alteration of the drug’s target site(s) within the microbe None of the other four answers are correct Rapid ejection (pumping) of the drug out of the microbial cell
- Define the following terms: Bactericidal Bacteriostatic AntisepsisWhich drug among the following inhibits bacterial protein synthesis by attaching to the bacterial 305 ribosome? Cefixime Amoxicillin OErythromycin DoxycyclineThe type of antimicrobial drug that would be most likely to have toxic effects in humans based on the premise of selective toxicity when treating microbial infection would be a drug that O 1) inhibits the synthesis of the cell wall O 2) inhibits metabolic pathways O 3) disrupts the cytoplasmic membrane 4) inhibits protein synthesis 5) All of the above have equal potential to be toxic
- To describe: The reasons for which passive transport is required for the bacteria.Which of the following mechanisms of action of antibiotics has the fewest side effects? protein synthesis cell wall synthesis DNA replication synthesis of essential metabolites enzymatic activitylist 3 different mechanisms of antibacterial drugs. Example: acting on cell wall, cell membrane, etc
- Discuss why it is important for us to conduct research at the basic level of physiology in order to better understand what makes Mycobacteria latent or grow during an infection so that we can design new and/or better treatment modalities.Identify a correct statement about tetracyclines. Multiple Choice They have a narrow antibacterial spectrum. They are bactericidal in nature. They bind irreversibly to bacterial ribosomes to inhibit bacterial protein synthesis. Their widespread use has allowed the emergence of bacterial resistance.Describe the classes of antibacterial drugs that act on the cell walland membrane, and list some of their applications.