When the compound I is replaced by compound II for anti-fungal activity, it was found that II has less side effects on the central nervous system (CNS) compared to I. The most likely explanation is: CI N. OH .CI II O The sulfur containing ring in I was easily converted into a toxic metabolite by the enzymes present in the CNS. O Replacement of Cl atoms by F leads to higher solubility in body fluids. O Il is more polar than I, hence it cannot cross the blood brain barrier easily. O The triazole rings in II is more bioorthogonal
When the compound I is replaced by compound II for anti-fungal activity, it was found that II has less side effects on the central nervous system (CNS) compared to I. The most likely explanation is: CI N. OH .CI II O The sulfur containing ring in I was easily converted into a toxic metabolite by the enzymes present in the CNS. O Replacement of Cl atoms by F leads to higher solubility in body fluids. O Il is more polar than I, hence it cannot cross the blood brain barrier easily. O The triazole rings in II is more bioorthogonal
Chapter19: Aldehydes And Ketones: Nucleophilic Addition Reactions
Section19.SE: Something Extra
Problem 29VC
Related questions
Question
Expert Solution
This question has been solved!
Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.
This is a popular solution!
Trending now
This is a popular solution!
Step by step
Solved in 2 steps
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, chemistry and related others by exploring similar questions and additional content below.Recommended textbooks for you
Organic Chemistry
Chemistry
ISBN:
9781305580350
Author:
William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Publisher:
Cengage Learning
Organic Chemistry
Chemistry
ISBN:
9781305580350
Author:
William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Publisher:
Cengage Learning
Chemistry & Chemical Reactivity
Chemistry
ISBN:
9781337399074
Author:
John C. Kotz, Paul M. Treichel, John Townsend, David Treichel
Publisher:
Cengage Learning
Chemistry & Chemical Reactivity
Chemistry
ISBN:
9781133949640
Author:
John C. Kotz, Paul M. Treichel, John Townsend, David Treichel
Publisher:
Cengage Learning
Introduction to General, Organic and Biochemistry
Chemistry
ISBN:
9781285869759
Author:
Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres
Publisher:
Cengage Learning