Only answer Part D please The denaturation of a biological macromolecule may be described as an equilibrium:ProteinDenatureda. Show that the fraction of denatured macromolecules, 0, is related to the equilibriumconstant, Kd, byK.1+ Kdb. At pH=2, the standard enthalpy and entropy of formation for the denaturation of theenzyme chymotrypsin are 418 kJ/mol and 1.32 kJ K-' mol-', respectively. Use these datato generate a plot that shows the temperature dependence of 0. Assume the enthalpy andentropy change to be independent of temperature.c. The "melting temperature" of a biological molecule is defined as the temperature atwhich 0=1/2. Determine the “melting temperature" of chymotrypsin at pH=2.d. Calculate the Gibbs energy and the equilibrium constant for the denaturation ofchymotrypsin at pH=2 ant T=310 K. Is the protein stable under these conditions?

Protein will be more stable in that form which is having more concentration at equilibrium.

Answered: d. Calculate the Gibbs energy and the…

d. Calculate the Gibbs energy and the equilibrium constant for the denaturation of chymotrypsin at pH=2 ant T=310 K. Is the protein stable under these conditions?

Chemistry: The Molecular Science

5th Edition

ISBN:9781285199047

Author:John W. Moore, Conrad L. Stanitski

Publisher:John W. Moore, Conrad L. Stanitski

Chapter16: Thermodynamics: Directionality Of Chemical Reactions

Section: Chapter Questions

Problem 105QRT

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