Explain the principle of Loss of heterozygosity (LOH)

Principles Of Radiographic Imaging: An Art And A Science
6th Edition
ISBN:9781337711067
Author:Richard R. Carlton, Arlene M. Adler, Vesna Balac
Publisher:Richard R. Carlton, Arlene M. Adler, Vesna Balac
Chapter38: Computed Tomography
Section: Chapter Questions
Problem 15RQ
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Explain the principle of Loss of heterozygosity (LOH) 

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Chromosomes are present inside the cell nucleus and made up of DNA (Deoxyribonucleic acid) molecules which are tightly packed around the histone protein.

In normal human individual, there are 23 pairs of chromosomes ( 22 pairs of autosomes and 1 pair of sex chromosome) that is 46 chromosomes in total.

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