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Explain the reasons for the importance of crystallization step involved in the manufacturing of bulk drugs?
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- Decaffeinated coffee is produced by extracting the caffeine from coffee with a solvent. Initially dichloromethane (CH 2Cl 2) was used, but concerns arose over the ill health effects of trace amounts of CH 2Cl 2 remaining in the coffee. Why is caffeine soluble in CH 2Cl 2?Suggest any examples of PAT Tools used for Crystallisation of Small Molecule Drugs ( SMD) purification ?Why is fractional distillation more efficient than simple distillation when purifying liquid mixtures?
- explain why there is a differnce in the conductivity of tap water compared to distilled waterxDetermine the mole fraction of p-dichlorobenzene dissolved in 1.00L of cyclohexane that shifts the vapor pressure from 78mmHg to 70 mmHg. Can you determine the mass of solute dissolved?A chemistry student wishes to extract 2.34 g of compound X from 15 mL of an aqueous mixture. She has two solvents available with the following characteristics: Solvent Solubility of X in 100 mL of solvent Нехane 36.92 Chloroform 28.33 Water 16.52 However, the student only has enough hexane (exactly 10 mL) for one extraction. On the other hand, she has enough chloroform (exactly 20 mL) to perform either 1 extraction with 20 mL or 2 sequential extractions with 10 mL each.