(f) Which of the following is true about an enantiomer of Lunesta? Identify all that apply: (1) The enantiomer rotates plane-polarized light in the opposite direction as Lunesta. (2) The enantiomer is a mirror image of Lunesta. (3) The enantiomer has the opposite biological effects as Lunesta (i.e., it keeps you awake). (4) Lunesta does not have an enantiomer.
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- You came across an article debating the use of Prevacid® vs. Nexium®. While both drugs have the same therapeutic effect, one is sold as a racemate and the other is sold as a single enantiomer. Previous medications such as Thalidomide and Advair® have sparked a debate about the safety of drugs sold as a racemate. 3. What is an enantiomer? Give example(c) Explain, using mechanisms, why the (S)-enantiomer of ibuprofen (E) undergoes racemisation under acidic conditions in the body. (E) (S) CO₂H20. Identify each asymmetric carbon atom in the following examples, and determine (if chiral) the (R) or the (S) configuration. 21. Explain the terms with suitable examples: (a) Inductive and Field effects (b) Electromeric effect (c) Mesomeric effect (d) l-strain (e) B-strain (f) F-strain and (g) Hyperconjugation. 22. Draw the energy diagram of thermodynamic control and kinetic control of a reaction. 23. How can you classify the major reactive intermediates in organic chemistry? Give examples. 24. Write the mechanism of the following reaction: CH,OH Br 25. Write a rational mechanism for the reaction of 2-Methyl-2-butanol with a strong acid. 26. 1-Butanol is heated with HBr. Write the detailed mechanism of the reaction. 27. 2-Bromobutane is heated with NaOH. Write the detailed mechanism of the reaction.
- (a) Draw all other stereoisomers of the molecule , labelling meso forms (if any), and assign descriptors to chiral carbon atoms. (b) Including molecule below, label pairs of enantiomers and pairs of diastereomers. (c) If you were to distill a mixture of all the isomers, how many fractions could be obtained, and what is in each fraction?Identify the relationship between the following pairs of structures, then state whether they are enantiomers, diastereomers or identical. Help me answer iv., v., iv., vii. (last 4 sub part)a) Considering compounds 2a through 21, identify: ONE PAIR of geometric isomers; TWO PAIRS of enantiomers and THREE PAIRS of identical molecules. b) Give the names, including the configurations, of each of the geometric isomers and of each of the enantiomers. Draw the relevant structures in the space provided in the Answer Booklet. c) Sort compounds 2a, 2b, 2c, 2f and 2k in order of increasing solubility in water and briefly justify your ordering. 2 НО. AH H H anulta HOwno barwolset of ef 28nuor OH 2bc 2c ning) bi 10291 H WH 2 st brbot di OH Lacenoqoid OH to nabio ni one nt at dit st 2e OH "H OH bre 2a 2d 2g 2j H HO 2h 2k HO ...H di al nt o 2f 2i 21
- A) Phenol Red is a weakly acidic dye which is yellow in the HA form and red in the A form. What concentration of Phenol Red is required to obtain an absorbance of 0.50 at 550 nm at pH 7.8? Note: ε550 of A = 2.5 x 104 M-1 cm-1; ε550 of HA = 0; pKa = 7.8. B) What would the absorbance of the solution in part (a) be if the pH was 8.8?Is ibuprofen more effective when administered as an individual enantiomer? If so, which enantiomer is more effective? If Optically pure (S) - (+) - enantiomer of ibuprofen is more effective. Explain why?? why not (R) - (-)?????? Explain in details, show the chemistry mechanism to prove that.d) Identify one compound that is expected to have identical physical properties as structure II. (e) Other than structures III and VI, identify a stereoisomer with a different boiling point from that of structure II. (f) Other than structures IV, identify one diastereomer of structure I. (g) How many stereoisomers may be derived from structure V?
- (a) Draw the ring-flip isomer of the molecule. (b) Show which of the two is favored in the equilibrium between them, and explain why, showing all possible forms of strain in each of the isomers. (c) What is the stereochemical relationship between the two isomers? (d) Draw another stereoisomer of the molecule and show all the strains it contains.(i) Explain with the aid of a reaction mechanism why the synthesis is highly diastereoselective. (ii) Draw the structures of the enantiomer, and one epimer of J, and give definitions of these terms.Question: Explain the concept of chirality in chemistry and its importance in drug development. Additionally, provide an example of a chiral drug and discuss the challenges associated with its synthesis and administration.