FIGURE 16-3 Two examples show the consequences of point mutations at splice sites. (a) A C to T transition mutation leads to a GT dinucleotide in Point mutations can alter MRNA splicing (a) the exon, forming a new 5' splice site. As a result, 64 nucleotides at the end of an exon are spliced out. (b) A G to T transversion mutation would eliminate the GT GC AG AG Intron GT / *64 nt New 5' splice site formed Exon 5' splice site so the intron would be retained in the MRNA. (b) GT AG GT AG 5' splice site eliminated, intron retained

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
icon
Related questions
Topic Video
Question

In Figure 16-3a, what is the consequence of the new 5′
splice site on the open reading frame? In 16-3b, how big
could the intron be to maintain the reading frame (let’s
say between 75 and 100 bp)?

FIGURE 16-3 Two examples show the
consequences of point mutations at
splice sites. (a) A C to T transition
mutation leads to a GT dinucleotide in
Point mutations can alter MRNA splicing
(a)
the exon, forming a new 5' splice site. As
a result, 64 nucleotides at the end of an
exon are spliced out. (b) A G to T
transversion mutation would eliminate the
GT
GC
AG
AG
Intron
GT
/ *64 nt
New 5' splice
site formed
Exon
5' splice site so the intron would be
retained in the MRNA.
(b)
GT
AG
GT
AG
5' splice site eliminated,
intron retained
Transcribed Image Text:FIGURE 16-3 Two examples show the consequences of point mutations at splice sites. (a) A C to T transition mutation leads to a GT dinucleotide in Point mutations can alter MRNA splicing (a) the exon, forming a new 5' splice site. As a result, 64 nucleotides at the end of an exon are spliced out. (b) A G to T transversion mutation would eliminate the GT GC AG AG Intron GT / *64 nt New 5' splice site formed Exon 5' splice site so the intron would be retained in the MRNA. (b) GT AG GT AG 5' splice site eliminated, intron retained
Expert Solution
trending now

Trending now

This is a popular solution!

steps

Step by step

Solved in 2 steps

Blurred answer
Knowledge Booster
Gene expression
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.
Similar questions
  • SEE MORE QUESTIONS
Recommended textbooks for you
Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:
9780134580999
Author:
Elaine N. Marieb, Katja N. Hoehn
Publisher:
PEARSON
Biology 2e
Biology 2e
Biology
ISBN:
9781947172517
Author:
Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:
OpenStax
Anatomy & Physiology
Anatomy & Physiology
Biology
ISBN:
9781259398629
Author:
McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:
Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:
9780815344322
Author:
Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:
W. W. Norton & Company
Laboratory Manual For Human Anatomy & Physiology
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:
9781260159363
Author:
Martin, Terry R., Prentice-craver, Cynthia
Publisher:
McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)
Inquiry Into Life (16th Edition)
Biology
ISBN:
9781260231700
Author:
Sylvia S. Mader, Michael Windelspecht
Publisher:
McGraw Hill Education