Genes that cause Prader-Willi syndrome and Angelman syndrome are closely linked along chromosome 15. Although people with these syndromes do not usually reproduce, let’s suppose that a couple produces two children with Angelman syndrome. The oldest child (named Pat) grows up and has two children with Prader- Willi syndrome. The second child (named Robin) grows up and has one child with Angelman syndrome. A. Are Pat and Robin’s parents both phenotypically normal or does one of them have Angelman or Prader-Willi syndrome? If one of them has a disorder, state whether it is the mother or the father, and explain how you know. B. What are the sexes of Pat and Robin?

Human Anatomy & Physiology (11th Edition)
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Genes that cause Prader-Willi syndrome and Angelman syndrome
are closely linked along chromosome 15. Although people with
these syndromes do not usually reproduce, let’s suppose that a
couple produces two children with Angelman syndrome. The oldest
child (named Pat) grows up and has two children with Prader-
Willi syndrome. The second child (named Robin) grows up and
has one child with Angelman syndrome.
A. Are Pat and Robin’s parents both phenotypically normal or
does one of them have Angelman or Prader-Willi syndrome? If
one of them has a disorder, state whether it is the mother or the
father, and explain how you know.
B. What are the sexes of Pat and Robin?

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