Glucose-6 Phosphate Dehydrogenase and TPI Deficiencies 2 H+ Glucose-6-P GSH + GSH Reduced glutathione NADP+ Glucose-6-phosphate dehydrogenase H₂O₂ Hydrogen peroxide 0₂- Superoxide radical NADPH + H+ 6-Phosphogluconolactone GSSG Glutathione Oxidized reductase Glutathione peroxidase Aerobic respiration, drugs, fava beans glutathione 2 H₂O Detoxification ……………………… 0₂ SOD: superoxide dismutase GPx: glutathione peroxidase HK: hexokinase GSSG and GSH: glutathione, oxidized and reduced forms, respectively. CAT: catalase The diagram above gives important details about the HMP shunt. Superoxides/free radicals dis- rupt membrane lipids, causing changes in membrane permeability. The HMP shunt is expressed in liver cells, red blood cells, and in lipid-producing tissues. 1. Discuss how glycolysis is affected in G6PD patients, using the diagrams to explain your response. 2. How does this effect differ from TPI patients? 3. Why are red blood cells, but not the nervous system, affected in G6PD patients?
Glucose-6 Phosphate Dehydrogenase and TPI Deficiencies 2 H+ Glucose-6-P GSH + GSH Reduced glutathione NADP+ Glucose-6-phosphate dehydrogenase H₂O₂ Hydrogen peroxide 0₂- Superoxide radical NADPH + H+ 6-Phosphogluconolactone GSSG Glutathione Oxidized reductase Glutathione peroxidase Aerobic respiration, drugs, fava beans glutathione 2 H₂O Detoxification ……………………… 0₂ SOD: superoxide dismutase GPx: glutathione peroxidase HK: hexokinase GSSG and GSH: glutathione, oxidized and reduced forms, respectively. CAT: catalase The diagram above gives important details about the HMP shunt. Superoxides/free radicals dis- rupt membrane lipids, causing changes in membrane permeability. The HMP shunt is expressed in liver cells, red blood cells, and in lipid-producing tissues. 1. Discuss how glycolysis is affected in G6PD patients, using the diagrams to explain your response. 2. How does this effect differ from TPI patients? 3. Why are red blood cells, but not the nervous system, affected in G6PD patients?
Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter22: Gluconeogenesis, Glycogen Metabolism, And The Pentose Phosphate Pathway
Section: Chapter Questions
Problem 8P
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Transcribed Image Text:HANDOUT C
Glucose-6 Phosphate
Dehydrogenase and TPI Deficiencies
Glucose-6-P
GSH + GSH
Reduced
glutathione
2 H+
NADP+
H₂O₂
Hydrogen
peroxide
Glucose-6-phosphate
dehydrogenase
Superoxide
radical
NADPH + H+
6-Phosphogluconolactone
GSSG
Glutathione Oxidized
reductase
Glutathione
peroxidase
Aerobic respiration,
drugs, fava beans
glutathione
2 H₂O Detoxification
SOD: superoxide dismutase
GPx: glutathione peroxidase
HK: hexokinase
GSSG and GSH: glutathione, oxidized and reduced forms,
respectively
CAT: catalase
The diagram above gives important details about the HMP shunt. Superoxides/free radicals dis-
rupt membrane lipids, causing changes in membrane permeability. The HMP shunt is expressed
in liver cells, red blood cells, and in lipid-producing tissues.
1. Discuss how glycolysis is affected in G6PD patients, using the diagrams to explain your
response.
2. How does this effect differ from TPI patients?
3. Why are red blood cells, but not the nervous system, affected in G6PD patients?
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