Cell wall bullding blockD-Ala-D-Alal-Lys-tailNH,MeHeptapeptidebackboneR1R.R2ii)With the aid of the figure above showing the important features of the binding of Vancomycin(lower part) to a bacterial cell wall peptia discuss the antibiotic effect of Vancomycin.i)Vancomycin resistant strains often have a mutation in which one of the D-Ala moieties isexchanged to a D-lactate moiety. Discuss why this mutation makes the strain Vancomycin-resistant but still viable.iv)Glycoconjugate vaccines based on bacterial capsular polysaccharides have been used for 30years without any need for changes in their structures, while the flu vaccine, based onattenuated or killed virus particles, requires many different structures and a check each timewhen there is an epidemic that the right vaccine is used. Discuss the reason behind this. Cell wall bullding blockD-Ala-D-Alal-Lys-tailNH,MeHeptapeptidebackboneR1R.R2ii)With the aid of the figure above showing the important features of the binding of Vancomycin(lower part) to a bacterial cell wall peptia discuss the antibiotic effect of Vancomycin.i)Vancomycin resistant strains often have a mutation in which one of the D-Ala moieties isexchanged to a D-lactate moiety. Discuss why this mutation makes the strain Vancomycin-resistant but still viable.iv)Glycoconjugate vaccines based on bacterial capsular polysaccharides have been used for 30years without any need for changes in their structures, while the flu vaccine, based onattenuated or killed virus particles, requires many different structures and a check each timewhen there is an epidemic that the right vaccine is used. Discuss the reason behind this.

Vancomycin is a glycopeptide antibiotic used to treat a number of bacterial infections. It acts by…

H. Me Call wall bullding block D-Ala-D-Alal-Lys-tail Me Heptapeptide backbone Ri O. R H. R2 i) (lower part) to a bacterial cell wall With the aid of the figure above showing the important features of the binding of Vancomycin eptiadiscuss the antibiotic effect of Vancomycin. iii) Vancomycin resistant strains often have a mutation in which one of the D-Ala moieties is exchanged to a D-lactate moiety. Discuss why this mutation makes the strain Vancomycin- resistant but still viable. iv) Glycoconjugate vaccines based on bacterial capsular polysaccharides have been used for 30 years without any need for changes in their structures, while the flu vaccine, based on attenuated or killed virus particles, requires many different structures and a check each time when there is an epidemic that the right vaccine is used. Discuss the reason behind this.

H. Me Call wall bullding block D-Ala-D-Alal-Lys-tail Me Heptapeptide backbone Ri O. R H. R2 i) (lower part) to a bacterial cell wall With the aid of the figure above showing the important features of the binding of Vancomycin eptiadiscuss the antibiotic effect of Vancomycin. iii) Vancomycin resistant strains often have a mutation in which one of the D-Ala moieties is exchanged to a D-lactate moiety. Discuss why this mutation makes the strain Vancomycin- resistant but still viable. iv) Glycoconjugate vaccines based on bacterial capsular polysaccharides have been used for 30 years without any need for changes in their structures, while the flu vaccine, based on attenuated or killed virus particles, requires many different structures and a check each time when there is an epidemic that the right vaccine is used. Discuss the reason behind this.

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter28: Dna Metabolism: Replication, Recombination, And Repair

Section: Chapter Questions

Problem 21P

See similar textbooks

Similar questions

Describe the molecule shown in the image. Evaluation at Atomic Resolution of the Role of Strain in Destabilizing the Temperature Sensitive T4 Lysozyme Mutant Arg96-->His
Drug 1-Ivacaftor (VX-770): Ivacaftor is a potentiator that increases CFTR channel opening time. We know from cell culture studies that this increases chloride transport by as much as 50% from baseline and restores it closer to what would be expected in wild type CFTR. Basically, the drug increases CFTR activity by unlocking the gate that allows for the normal flow of salt and fluids. For which class of mutations do you think Ivacaftor will be most effective? Explain your choice.
I. A protein, X, was Isolated from a pathogenlc mlcroorganism. The proteln Is a vlrulence factor whose path0genlclty lies In a heptapeptide of unknown sequence. After trypsin cleavage of the heptapeptide from protein X, the peptlde's compOsition and sequence was determined. The fOllowing were the results of the sequenclng process: 1. When the peptide was treated with dinitrofluorobenzene (DNFB), DNP-asp and a mixture of amino acids were produced. 2. When the same Intact peptide was treated with streptococcal protease, a pentapeptide of composition asp, asN, cys, gly and ser and 2 amlno acids were released. 3. When the heptapeptlde was also treated with hydrOxylamine HCI, a tripeptide and a tetrapeptide were obtained. The C-terminal amino acid of the tripeptide was asN. 1) What is the sequence of the heptapeptide if it is composed of cys, asp, lys, asN, gly and ser only? 2) What is the pl of the heptapeptide?
The haemoglobin proteins of RNA polymerase ii sub units RPB1-P24928 RPB2-P30876 RPB3-P19387 RPB4-015514 are they similar? Explain?
Given that the multiplicity of infection of bacteriophage lambda to E' coti is greater than i.0, discuss in detail the most likely growth path that wiil be taken by bacteriophage lambda, and briefly explain your rationale.
(A) strain A strain B pro-Pase protease DOCKING pro-Pase protease SNARES exist as complementary partners that carry out membrane fusions between appropriate ves- icles and their target membranes. In this way, a vesicle with a particular variety of v-SNARE will fuse only with a membrane that carries the complementary t-SNARE. In some instances, however, fusions of identical membranes (homotypic fusions) are known to occur. For example, when a yeast cell forms a bud, vesicles derived from the mother cell's vacuole move into the bud where they fuse with one another to form a new vacuole. These vesicles carry both v-SNARES and t-SNARES. Are both types of SNARES essential for this homotypic fusion event? FUSION Pase (B) 100 75 To test this point, you have developed an ingenious assay for fusion of vacuolar vesicles. You prepare vesicles from two different mutant strains of yeast: strain B has a defective gene for vacuolar alkaline phosphatase (Pase); strain A is defective for the protease…
Why are structural analogs of sugar molecules (such as Oseltamivir and zanamivir) effective in treatment of influenza-virus infection?
Determine the sequence of a polypeptide treated with trypsin and chimotripsine. Below are the fragments generated with each treatment. Determine the original sequence for both fragmentations (reduerde that they must be equal in the order of amino acids) Quimotripsina 1. Leu-His-Lys-Gln-Ala-Asn-Gln-Ser-Gly-Gly-Gly-Pro-Ser 1. Gln-Gln-Ala-Gln-His-Leu-Arg-Ala-Cys-Gln-Gln-Trp 2. Arg-lle-Pro-Lys-Cys-Arg-Lys-Phe Trypsin 1. Arg 2. Ala-Cys-Gln-GIn-Trp-Leu-His-Lys 3. Cys-Arg 4. Gln-Ala-Asn-Gln-Ser-Gly-Gly-Gly- Pro-Ser 5. lle-Pro-Lys 6. Light 7. Phe-Gin-Gln-Ala-Gln-His-Leu-Arg
I was wondering if it is possible to provide an explanation on the structure of the PDB code 2V1X, the amino acid at position 219 and the mutation of the amino acid name LU. Thank you.
Various antimicrobial drugs to treat microbial infection have diverse mechanism of action. Consider the following antimicrobial drugs: A. Seconeolitsine, known as DNA topoisomerase I inhibitor in bacteria. (i) Explain briefly how inhibiting DNA topoisomerase I is a good mechanism of action for an antibiotic, include possible molecular machineries being targeted. (ii) What would be an appropriate response if seconeolitsine works well by stating the state of supercoiling in bacteria. (iii) To prove your answer (ii), you test the condition of bacterial DNA by running gel electrophoresis, one has been treated with seconeolitsine (+ sample) and the other one is not (- sample). Explain the position of each + sample and – sample band on the gel in reference to the point of origin (where you load your samples) or how far each DNA sample travel across agarose gel. (iv) Explain why you would expect answer (iii) for each + sample and – sample. B.…
Translation in eukaryotes and prokaryotes are similar and yet different. From a therapeutic perspective, why is this advantageous?
Part A What kind of inhibition is imposed on HIV protease by ritonavir? O irreversible inhibition O reversible inhibition O uncompetitive inhibition. Submit Request Answer