If this molecule can inhibit toxic effects at 0.5mM against gastric carcinoma cells, does it mean that the dimer of this nucleoside analogue will exhibit an IC50 of about 0.25mM?

Q: Based on the figure and the explanation in the textbook, what are the random chances that the…

A: Denaturation is the process by which proteins lose their native conformation. Ribonuclease A has 124…

Q: 2,3-Bisphosphoglycerate lies in a central cavity within the hemoglobin tetramer, stabilizing the T…

A: BPG is present in the RBCs of human beings and other species. It is a highly charged anion. In…

Q: CYP2E1 has a much higher Km for ethanol than ADH (11 mM versus 0.05 mM, respectively). When greater…

A: km that is Michaelis Menten's constant is a substrate concentration of the enzyme catalysed reaction…

Q: . Most bacterial mutants that require isoleucine for growth also require valine. Why? Which enzyme…

A: A mutation is a permanent alteration in the sequence of nitrogenous bases of a DNA molecule.

Q: n a rat cardiomyocyte, the levels of creatine, phosphocreatine, and free phosphate were found to be…

A: Gibbs's free energy is a measure of chemical energy. All chemical systems move naturally towards…

Q: Peptide Y is a polymorphic analogue of Peptide X. If peptide X with endorphin-like property was…

A: Streptococcal protease could be any of the serine protease. as streptococcus is the general source…

Q: What are the subunit interactions that account for the properties of ATCase?

A: Enzymes help to speed up various chemical reactions occurring in a human body as they are also known…

Q: Sodium nitrite, a common food preservative (page 906), is capable of causing mutations in an acidic…

A: Sodium nitrite, a common food preservative , is capable of causing mutations in an acidic…

Q: How does the "sequential" model, used to describe allosteric regulation, explain negative…

A: Allosteric regulation and negative cooperativity - Allosteric regulation of enzymes suggest that…

Q: What are the possible sources of errors or deviations between the theoretical and experimental pKa…

A: pKa value: pKa or Acid dissociation constant is also known as acidity constant or acid-ionization…

Q: Given a primer sequence 3’- CTGGGAAACATTCTGGAT - 5’, compute for the melting temperature of this…

A: Melting temperature of primer can be defined as a temperature at which one half of the DNA double…

Q: Bovine ribonuclease folds with ΔH° = -280 kJ mol-1 and ΔS° = -0.79 kJ mol-1 K -1. Assume ΔH° and ΔS°…

A: The basis for predicting spontaneity of a reaction is based on (ΔG), the change in G, at constant T…

Q: Given the following Hill Plot, what is the Kp for the last binding site? log Y 1-Y 2.5 0 -2.5 2.5…

A: Kd is dissociation constant and used to express the affinity of a protein for a ligand. A lower…

Q: What function does a guanine nucleotide exchange factor(GEF) serve?

A: Small GTPases or small G-protein is a type of hydrolase enzyme found in the cytosol of the cell.…

Q: In oxygenated hemoglobin, pKa 5 6.6 forthe histidines at position 146 on the -chain. In…

A: Bohr effect - With increasing H+ concentration (lower pH) or when hemoglobin is exposed to increased…

Q: A protein sample of unknown concentration was placed in a cuvette with a path length of 1 cm and the…

A: The concentration of a protein is directly proportional to the amount of light it absorbs. The…

Q: In 1925, Briggs and Haidane reported on the modifications of the michaelis-menten equation. Briefly…

A: Michaelis Menten equation relates reaction velocity with the concentration of substrate. Here, the…

Q: Explain why cleavage of the bond between arginine 15 and isoleucine 16 of chymotrypsinogen activates…

A: Enzymes are known as biological catalysts in which help to catalyze the different biochemical…

Q: For the following concentrations, determine the equivalent of a. 75ug/mg lyophilized protein in ppm…

A: Proteins are a type of macromolecule that have a variety of roles in biological processes. It is…

Q: Given a tripeptide Cys-His-Lys,   Cys: Pk1 = 1.71; Pk2 = 10.78; PkR = 8.33 His: Pk1 = 1.82; Pk2 =…

A: The pKa values of amino acid side chains that constitute a protein play an important role in…

Q: In trimetric G proteins the only function of the bamma y complex is to allow reactivating of the a…

A: G proteins are called the guanine nucleotide proteins that are responsible for switching on and off…

Q: The SARS-CoV-2 spike protein is heavily glycosylated. What are some of the monosaccharides found in…

A: The spike (S) protein of SARS-CoV-2 mediates the virus binding to the human cells via its…

Q: In biochemical and structural terms, how does the cellular form of the prion protein differ from the…

A: There are different macromolecules present in the living organism. Of which proteins are one of the…

Q: 6.3.7 Activity (1) List and briefly explain four methods of studying an E-S complex. (2) (a) Which…

A: When an enzyme comes into perfect contact with its substrate, a transient molecule called the enzyme…

Q: If 32p – labeled (radioactive phosphate) inorganic phosphate were introduced to erythrocytes…

A: Glycolysis convert glucose into pyruvate or lactate with generation of energy. It occurs in all…

Q: If the molecule can inhibit toxic effects at 0.5mM against gastric carcinoma cells, does it mean…

A: IC 50 is half maximal inhibitory concentration which measures potency of substance to inhibiting…

Q: 25) Although the UV280 extinction coefficient of BSA is well known, why was the BCA assay employed…

A: Protein assays normally used to standards to quantify quality of other protein, by comparing unknown…

Q: An increase in HDACS can lead to which of the following?

A: Ans - D) All of the above Chromatin's fundamental structure is known as nucleosome and it consists…

Q: What is the dominant biochemical activity or molecular interaction that Sickle Cell Anemia…

A: Hemoglobin is an oligomeric conjugated protein with four peptide chains joined by a…

Q: Individuals with phenylketonuria cannot convert phenylalanine to tyrosine. Why don’t these…

A: Inborn errors of metabolism are uncommon hereditary (inherited) disorders in which the body can't…

Q: . What physiological effect would you predict from a mutation that replaced with serine the cysteine…

A: Immunoglobulin (Ig), is considered as the protein, which is produced by the immune cells such as…

Q: Carbohydrates can play important roles by modulating interactions between proteins. For example,…

A: Thrombin (coagulation factor II) is a serine protease that plays a vital role in hemostasis and…

Q: If the molecule can inhibit toxic effects at 0.5mM against gastric carcinoma cells, does it mean…

A: IC50 is the half inhibitory maximum concentration of a drug which inhibits the process 50%.

Q: Why is there no net gain of methionine if homocysteine isconverted to methionine with…

A: Methionine is an amino acid which is found in meat, fish and dairy products and it plays an…

Q: Antithrombin III forms an irreversible complex with thrombin but not with prothrombin. What is the…

A: The blood cell is also called a hematopoietic cell. It is produced by the process named…

Q: In pyrimidine nucleosides, the anti conformation predominates. Explain. Do the purine nucleosides…

A: Introduction and Explanation: Pyrimidines and purines are the nitrogenous bases that are present in…

Q: Bisphosphoglycerate lies in a central cavity within the hemoglobin tetramer, stabilizing the T…

A: Hemoglobin (Hb) is the protein complex, which is a tetramer in a structure that binds to the oxygen…

Q: In studies using repeating copolymers, AC . . . incorporates threonine and histidine, and CAACAA . .…

A: A protein's amino acid sequence is determined by the sequence of nucleotides in DNA and RNA.  It is…

Q: Most bacterial mutants that require isoleucine for growth also require valine.Why? Which enzyme or…

A: Mostly the bacteria that require the isoleucine amino acid for growth also requires valine. This is…

Q: A mutant is found that has the following protein sequence: Met Gly Thr Leu Arg Gly. What is the…

A: Mutation is defined as the alteration in gene that result in alteration in the function of the…

Q: Explain the 7-methylguanosine (m7G) ? Define its importance ?

A: The glycosylamines that can be thought of as nucleotides without a phosphate group are known as the…

Q: This molecule forms a dimer via pi interactions, resulting to effective molecular stacking. If the…

A: IC50 is the half maximal inhibitory concentration of a drug that is important to know the amount of…

Q: Using the following data, determine the correct sequence of the octapeptide. Edmund's Reaction =…

A: Chains of Amino acids are held together through a peptide bond to form a structure known as…