In a study of healthy volunteers, chewed aspirin has indicated a faster (5 min) effect as opposed to regular swallowed aspirin (12 minutes).  Which of the following mechanisms explains the above effect? Chewing allows for aspiring to act faster as a reversible COX-1 inhibitor. Chewing allows for faster dissolution time to reach its peak effect quicker. Chewing allows for aspiring to act faster as a reversible inhibitor for thromboxane A2.

Curren'S Math For Meds: Dosages & Sol
11th Edition
ISBN:9781305143531
Author:CURREN
Publisher:CURREN
Chapter10: Reconstitution Of Powdered Drugs
Section: Chapter Questions
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. In a study of healthy volunteers, chewed aspirin has indicated a faster (5 min) effect as opposed to regular swallowed aspirin (12 minutes).  Which of the following mechanisms explains the above effect?

  1. Chewing allows for aspiring to act faster as a reversible COX-1 inhibitor.
  2. Chewing allows for faster dissolution time to reach its peak effect quicker.
  3. Chewing allows for aspiring to act faster as a reversible inhibitor for thromboxane A2.
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