In humans, Huntington's Disease is an autosomal dominant trait. Huntington's Disease has late onset, it manifests in the 40s and 50s, usually after the individual has reproduced. Symptoms are progressive and the affected patient, needs continuous support later on as the disease advances. A couple in which a woman had a father not affected, and a mother that died of Huntington's Disease, and had both parents also affected, plans to have 6 children with a man who has not history of this disorder in his family, is in his 50s and it is not affected. A) Please state the genotypes of the parents. Use H to denote the dominant allele and h as the recessive B) Determine the probability that the first 3 children born will have Huntington's Disease and the three last children will not. C) In general, what proportion of the children are expected to be female and suffer Huntington's disease trait? D) What is the probability that 4 of the children will exhibit Huntington's and two children not be affected?

In humans, Huntington's Disease is an autosomal dominant trait. Huntington's Disease has late onset, it manifests in the 40s and 50s, usually after the individual has reproduced. Symptoms are progressive and the affected patient, needs continuous support later on as the disease advances. A couple in which a woman had a father not affected, and a mother that died of Huntington's Disease, and had both parents also affected, plans to have 6 children with a man who has not history of this disorder in his family, is in his 50s and it is not affected. A) Please state the genotypes of the parents. Use H to denote the dominant allele and h as the recessive B) Determine the probability that the first 3 children born will have Huntington's Disease and the three last children will not. C) In general, what proportion of the children are expected to be female and suffer Huntington's disease trait? D) What is the probability that 4 of the children will exhibit Huntington's and two children not be affected?

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter5: The Inheritance Of Complex Traits

Section: Chapter Questions

Problem 23QP: If diseases such as cardiovascular disease (hypertension and atherosclerosis) are familial, is this...

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