make a flow chart of a drug and show its metabolism noting if there are active metabolites where phase one metabolism occurs, where phase two metabolsm occurs and with what enymes
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aside from cocaine or heroin, make a flow chart of a drug and show its
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- make a flow chart of a drug and show its metabolism noting if there are active metabolites where phase one metabolism occurs, where phase two metabolsm occurs and with what enymesGive an example of N-dealkylation and oxidative deamination over the active molecule of a drug and indicate which type of metabolization they are.Draw the structures of the major metabolites you would predict (Phase I and Phase II) for the non-steroidal anti-inflammatory drug naproxen and the beta blocker propranolol (use hand drawn illustrations or free chemistry drawing software, e.g. Marvin, for your answer). Explain how these metabolites are formed and comment on the role of metabolism (Phase I and Phase II) in the detoxification of the drugs.
- Explain what indole alkaloids are. And describe the significance of vinflunine.For a weak ester drug that is unstable in highly acidic or alkaline solutions, what strategies could be used to make this drug more bioavailable after oral administration?Which of these heterocyclic drugs is likely to be the least soluble in water? Use the Fsp³ parameter to decide. OH Tramadol Chemical Formula: C16H25NO2 YOUR OW Pantoprazole Torasemide Chemical Formula: C16H15F2N3O4S Chemical Formula: C16H20N4O3S Temazepam -OH Chemical Formula: C16H13CIN₂O2 Tioconazole Chemical Formula: C16H13C3N₂OS A. Tramadol B. Pantoprazole C. Torasemide D. Temazepam E. Toconazole