Microbial products trigger macrophage activation. Match the receptor with the product that it binds. ✓ TLR-4 ✓ TLR-3 ✓ TLR-9 ✓ TLR-5 A. Unmethylated DNA B. Double-stranded RNA C. LPS D. Flagella
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- Which of the following statements regarding phagocyte recognition of pathogens is TRUE? TLRS in the phagocyte cytoplasmic membrane bind surface structures of microbes. O TLRS on the surface of microbes trigger the accumulation of opsonins. O Lectins on the surface of microbes are bound by chemokine receptors. NOD proteins on the surface of microbes are detected by TLRS. Question 3 A person has a disease that has activated the first line of defense. Which of the follcaToll-like receptors represent an ancient pathogen-recognition system. The first pattern recognition receptor (PRR) important in innate immune responses was discovered in the fruit fly Drosophila melanogaster. Stimulation of this receptor, called Toll, induces: The synthesis of prostaglandins and leukotrienes The inflammatory response in Drosophila hemolymph vessels The production of antimicrobial peptides The recruitment of phagocytic cells to the site of infection The activation of Drosophila complementDRAW IT Sketch a B cell antigen receptor. Label the Vand C regions of the light and heavy chains. Label theantigen-binding sites, disulfide bridges, and transmembrane region. Where are these features located relativeto the V and C regions?
- phagocytic cells recognize pathogen-associated molecular patterns using their: Group of answer choices phagosomes perforins pyrogens pattern-recognition receptorsWhich of the following statements is NOT correct? Group of answer choices -Natural killer cells are cytolytic lymphocytes that mediate ADCC -Neutrophils carry out phagocytosis of C3b-tagged particles -Macrophages carry out phagocytosis of C3b-tagged particles -Mast cells produce granules containing the cytotoxin perforin -B lymphocytes express a receptor for complement proteinsA patient develops a blood infection with a capsule-producing strain of E. coli. Phagocytosis by macrophage will be essential to destroy the bacteria and resolve the infection. Which of the following will be dirertly required to allow ADCC-opsonization of the encapsulated E. coli: O Toll-like receptor (TLR)-induced secretion of tumor necrosis factor alpha O Release of C3a to the extracellular fluids O Presence of MHC II on the surface of the macrophage O Presence of IgG receptors (Fc-gamma-R) on the macrophage All of the answers apply
- Write TRUE is the statement is True, otherwise write FALSE and explain why the statement is False. The complement system involves a set of genes that distinguish foreign cells from body cells. The alternative complement activation pathway involves the cleavage of C5 to form C9. The type of interferon present late in an infection is gamma interferon. Interferons cause muscle aches, chills, and fever. Toll-like receptors act to cause phagocytic chemotaxis. Lymphocytes are large agranulocytes. Opsonization occurs when a phagocyte’s pseudopods surround a microbe and fuse to form a sac. Defensins are antimicrobial peptides of the first line of defense.Which of the following is true about innate immune system? Check all that apply. Rig-I-like receptors have the advantage of recognizing viruses by interacting with their spike proteins TLR signaling includes NF-kB pathways to induce synthesis of proinflammatory cytokines TLR binds to dsDNA or ssRNA to induce interferon gene expression PRR induced secretion of proinflammatory cytokines and chemokines have local and systemic effects PRR induces innate immunity; phagocytosis, inflammation, type I interferon production, and regulate adaptive immunity; DC maturation, costimulatory molecules, type I interferonThe alternative pathway is an amplification loop for C3b formation that is accelerated by properdin in the presence of pathogens. The alternative pathway of complement activation has an important role in innate immunity, due to its ability to greatly amplify the amount of C3b deposited onto the pathogen surface. This amplification occurs because: The C3 convertase of the alternative pathway is much more active than those of the classical and lectin pathways. The C3 convertase of the alternative pathway works as a soluble enzyme in the plasma. The C3 convertase of the alternative pathway cannot be inactivated by complement regulatory factors in the host. The C3 convertase of the alternative pathway is more efficiently recruited to pathogen surfaces than the C3 convertases of the classical and lectin pathways. The C3 convertase of the alternative pathway contains C3b, and can generate more of itself.
- Alpha Beta chain chain CHO CHO Disulfide bridge CHO CHO What kind of receptor is show in the figure? T-cell receptor impossible to tell B-cell receptor Variable region "V" Constant region "C" Hinge "H Transmembrane region Cytoplasmic tailWhich of the following is true about innate immune system? Check all that apply. PAMPs recognize pathogen recognition receptors (PRRs) such as TLRs, NLRs and RLRs present on/in host cells TLRs that are expressed on cell surface are mostly recognized by viruses, whereas intracellular TLRs are recognized by bacteria PRRs can induce inflammatory response, opsonization and phagocytosis Pattern associated molecular patterns (PAMPs) are molecules such as CpG DNA, cytosolic dsDNA and RNAs made by the host cellMatch the term with its description. interferon response apoptosis extravasation respiratory burst acute-phase response Drag answer here. Drag answer here Drag answer here Drag answer here Drag answer here temporary rise in oxygen consumption and toxic oxygen species production a notable rise or reduction of plasma proteins in response to IL-6 cellular suicide characterized by DNA fragmentation stimulates inhibition of viral replication migration of neutrophils into inflamed tissues
