Naltrexone is not used in this way because naltrexone:

Ebk:Nutrition & Diet Therapy
10th Edition
ISBN:9780357391747
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Chapter15: Medications, Diet-drug Interactions, And Herbal Products
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Naloxone is sometimes added to PO phenanthrene formulations to reduce injection abuse while retaining pain relief when used properly. Naltrexone is not used in this way because naltrexone:

1. is orally bioavailable

2. will reduce conversion of the opioid pro-drug

3. will cross the blood brain barrier.

4. has a longer half-life

5. should only be used for opioid maintenance therapy

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