Neurons are especially vulnerable to defects in transport due to the extreme length of the neuronal processes. Abnormal accumulations of proteins and organelles have been observed in cells of patients with Huntington's, Parkinson's and Alzheimer's disease. Several mutations hinder neuronal transport pathways Which of these proteins would you expect to be mutated in the above cells? Select all that apply. microtubule based motor proteins O alpha keratin alpha tubulin O actin binding protein, filamin

Neurons are especially vulnerable to defects in transport due to the extreme length of the neuronal processes. Abnormal accumulations of proteins and organelles have been observed in cells of patients with Huntington's, Parkinson's and Alzheimer's disease. Several mutations hinder neuronal transport pathways Which of these proteins would you expect to be mutated in the above cells? Select all that apply. microtubule based motor proteins O alpha keratin alpha tubulin O actin binding protein, filamin

Biology: The Dynamic Science (MindTap Course List)

4th Edition

ISBN:9781305389892

Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan

Publisher:Peter J. Russell, Paul E. Hertz, Beverly McMillan

Chapter9: Cell Communication

Section: Chapter Questions

Problem 3ITD

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Usually , rates of diffusion vary inversely with molecular weights; so smaller molecules diffuse faster than do larger ones. In cells, however, calcium ion diffuses more slowly than does cAMP. Propose a possible explanation.
a skeletal muscle cell has depleted its stores of ATP how will the altered transport properties of the NKA transporter affect cytosolic calcium concentrations (increase, decrease, no change) relative to normal? Why?
If the RGD tripeptide sequence in fibronevtin wete absent. Which is true? integrims would not bind to fibronectin cadherins on adjacent cells would not be able to interact in a homotypic fashion. fibronectin could not form crosslink with other extracellular matrix proteins. glycosaminoglycans would not be able to assemble onto proteoglycans.
rate of transport Vmax 1/2Vmax transporter-mecated diffusion Km simple diffusion concentration of transported molecule The graph at left shows rates of movement across a cell membrane for a substance that uses simple diffusion (green) and a transport mechanism (red). Which of the following is TRUE about the transporters at the point shown by the arrow? A. The transporter proteins are operating more slowly than at lower concentrations. B. The transporter proteins are operating as fast as possible. C. The transporters proteins shut off at that concentration. D. The rate slows because transporter proteins run out of ATP.
pQLScB3CBS-8U2yQp5UAPJA-R3spS6YB8srqTGBoSwdXc_EattnA/viewform dvisor Main... My Drive - Google... Your answer What is the difference between primary active transport and secondary active transport? The sodium potassium pump * Job Listing - USF... WT Enrollment Requir... Is a symporter Can be blocked with drugs Controls intracellular chloride and potassium concentrations Is a glycolipid Breaks down ATP in order to generate energy ATP can be broken down to generate energy * True False A copy of your responses will be emailed to lc21-0506@lclark.edu. Submit Chemic Cle
It is not an easy matter to assign particular func-tions to specific components of the basal lamina, sincethe overall structure is a complicated composite materialwith both mechanical and signaling properties. Nidogen,for example, cross-links two central components of thebasal lamina by binding to the laminin γ-1 chain and totype IV collagen. Given such a key role, it was surprisingthat mice with a homozygous knockout of the gene fornidogen-1 were entirely healthy, with no abnormal phe-notype. Similarly, mice homozygous for a knockout of thegene for nidogen-2 also appeared completely normal. Bycontrast, mice that were homozygous for a defined muta-tion in the gene for laminin γ-1, which eliminated just thebinding site for nidogen, died at birth with severe defectsin lung and kidney formation. The mutant portion of thelaminin γ-1 chain is thought to have no other functionthan to bind nidogen, and does not affect laminin struc-ture or its ability to assemble into the basal lamina.…
Although purified actin can assemble reversibly in vitro, various actin-binding proteins regulate the assembly of actin filaments in the cell. Predict the effect on a cell’s actin cytoskeleton if function-blocking antibodies against each of the following were independently microinjected into cells: profilin, thymosin-β4, CapZ, and the Arp2/3 complex.
the sodium channel exchanger NCX transports sodium into and calcium out of cardiac muscle cells. Describe why this itransporter is classified as secondary active transport?
When nerve cells contact each other, they form adherens junctions (AJs) at the point of contact. The main transmembrane (TM) protein in the junctions is N-cadherin. N-cadherin is a single pass TM protein with a short intracellular domain and a large extracellular domain on the amino end. Proper formation of the AJs requires both actin (MF) and microtubules (MTs). Motor proteins for MTs are dynein (-) end and kinesin (+) end (and were discovered by Michael Sheetz). Maintenance of preformed AJs requires MFs . Adding drugs that disrupt MFs causes AJs to fall apart, and the N-cadherin is removed from the PM (by endocytosis). If the drugs are removed, MTs (& MFs) are required to restore the N-cadherin to the plasma membrane. choose answer for D1 and D2 D. Suppose cells contain a soluble kinase that modifies N-cadherin that has been removed from the PM. D-1. The kinase could catalyze modification(s) of the side chains of amino acids near (the N end) (the C end) (either end, but not…
6) Consider the mechanism of net NaCl secretion across an epithelium shown below (in attachment) What provides the driving force for Cl- entry through the basolateral membrane into cell?
Define anterograde axoplasmic transport. Why is this type of axonal transport necessary in most neurons? And, briefly describe the molecules involved in facilitating anterograde transport 2
If a skeletal muscle has depleted its stores of ATP how will the altered transport properties of the following transporters affect cytosolic ion concentrations (increase, decrease, no change) relative to normal? Skeletal Muscle Cell With Depleted ATP Stores Ion transporter Cytosolic K+ Cytosolic Na+ Cytosolic Ca2+ NKA NCX SERCA