neurosurgeon believes that lesions in a particular area of the brain, called the thalamus, will decrease pain perception. If so, this could be important in the treatment of terminal illness that is accompanied by intense pain. As a first attempt to test this hypothesis, he conducts an experiment in which 16 rats are randomly divided into two groups of eight each. Animals in the experimental group receive a small lesion in the part of the thalamus thought to be involved with pain perception. Animals in the control group receive a comparable lesion in a brain area believed to be unrelated to pain. Two weeks after surgery, each animal is given a brief electrical shock to the paws. The shock is administered in an ascending series, beginning with a very low intensity level and increasing until the animal first flinches. In this manner, the pain threshold to electric shock is determined for each rat. The following data are obtained. Each score represents the current level (milli-amperes) at which flinching is first observed. The higher the current level is, the higher is the pain threshold. Note that one animal died during surgery and was not replaced. Neutral Area Lesions Thalamic Lesions 0.8 1.9 0.7 1.8 1.2 1.6 0.5 1.5 0.4 1.0 0.9 0.9 1.4 1.7 1.1 Is there any decrease pain perception on the lesions of the thalamus? Give the following: 1. State the null and alternative hypothesis. 2. Identify sample size and alpha level 3. Determine Statistical tools 4. Computation (p-value and r-value) 5. Decision
A neurosurgeon believes that lesions in a particular area of the brain, called the thalamus, will decrease pain perception. If so, this could be important in the treatment of terminal illness that is accompanied by intense pain. As a first attempt to test this hypothesis, he conducts an experiment in which 16 rats are randomly divided into two groups of eight each. Animals in the experimental group receive a small lesion in the part of the thalamus thought to be involved with pain perception. Animals in the control group receive a comparable lesion in a brain area believed to be unrelated to pain. Two weeks after surgery, each animal is given a brief electrical shock to the paws. The shock is administered in an ascending series, beginning with a very low intensity level and increasing until the animal first flinches. In this manner, the pain threshold to electric shock is determined for each rat. The following data are obtained. Each score represents the current level (milli-amperes) at which flinching is first observed. The higher the current level is, the higher is the pain threshold. Note that one animal died during surgery and was not replaced.
|
Neutral Area Lesions |
Thalamic Lesions |
|
0.8 |
1.9 |
|
0.7 |
1.8 |
|
1.2 |
1.6 |
|
0.5 |
1.5 |
|
0.4 |
1.0 |
|
0.9 |
0.9 |
|
1.4 |
1.7 |
|
1.1 |
|
Is there any decrease pain perception on the lesions of the thalamus?
Give the following:
1. State the null and alternative hypothesis.
2. Identify sample size and alpha level
3. Determine Statistical tools
4. Computation (p-value and r-value)
5. Decision
6. Conclusion
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