In the conversion of acetone to aceto-cyanohydrin, the effect of electron-donating substituents on the tetrahedral intermediate isto:stabilize the charge on oxygendestabilize the carbocation formeddestabilize the chcharge on oxygenmake the intermediate more crowdedWhich of the following is not indicated by this reaction?KI, H;PO4ether, 25° CThe reaction occurs in solution.It occurs at room conditions.The reaction is carried out with an acid catalyst.The solvent is KI.Predict the increasing rate of reaction of the following alkenes with HCI.1. 2-buteneII. 2-methyl-2-buteneII. ethene(A I, II, IIB II, I, IIII, III, IIII, I, II

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ng is not indicated by this reaction? KI, H;PO4 ether, 25° Č

Organic Chemistry

9th Edition

ISBN:9781305080485

Author:John E. McMurry

Publisher:John E. McMurry

Chapter21: Carboxylic Acid Derivatives: Nucleophilic Acyl Substitution Reactions

Section21.SE: Something Extra

Problem 41MP

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Concept explainers

Reactions of Ethers

Ethers (R-O-R’) are compounds formed by replacing hydrogen atoms of an alcohol (R-OH compound) or a phenol (C6H5OH) by an aryl/ acyl group (functional group after removing single hydrogen from an aromatic ring). In this section, reaction, preparation and behavior of ethers are discussed in the context of organic chemistry.

Epoxides

Epoxides are a special class of cyclic ethers which are an important functional group in organic chemistry and generate reactive centers due to their unusual high reactivity. Due to their high reactivity, epoxides are considered to be toxic and mutagenic.

Williamson Ether Synthesis

An organic reaction in which an organohalide and a deprotonated alcohol forms ether is known as Williamson ether synthesis. Alexander Williamson developed the Williamson ether synthesis in 1850. The formation of ether in this synthesis is an SN2 reaction.

Question

In the conversion of acetone to aceto-cyanohydrin, the effect of electron-donating substituents on the tetrahedral intermediate is
to:
stabilize the charge on oxygen
destabilize the carbocation formed
destabilize the ch
charge on oxygen
make the intermediate more crowded
Which of the following is not indicated by this reaction?
KI, H;PO4
ether, 25° C
The reaction occurs in solution.
It occurs at room conditions.
The reaction is carried out with an acid catalyst.
The solvent is KI.
Predict the increasing rate of reaction of the following alkenes with HCI.
1. 2-butene
II. 2-methyl-2-butene
II. ethene
(A I, II, II
B II, I, II
II, III, I
III, I, II

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