Now that we have synthesized the required aldehyde, the synthesis of ketone A can be accomplished, starting with a different disubstituted alkene: A The transformation above can be performed with some reagent or combination of the reagents listed below. Give the necessary reagent(s) in the correct order, as a string of letters (without spaces or punctuation, such as “EBF"). If there is more than one correct solution, provide just one answer. A B t-BUOK HBr, ROOR 1) 2) H3O* workup D F HBr DMP or PCC Mg G H TSCI, py NBS, hv Na2Cr207, H2SO4, H2O

Now that we have synthesized the required aldehyde, the synthesis of ketone A can be accomplished, starting with a different disubstituted alkene: A The transformation above can be performed with some reagent or combination of the reagents listed below. Give the necessary reagent(s) in the correct order, as a string of letters (without spaces or punctuation, such as “EBF"). If there is more than one correct solution, provide just one answer. A B t-BUOK HBr, ROOR 1) 2) H3O* workup D F HBr DMP or PCC Mg G H TSCI, py NBS, hv Na2Cr207, H2SO4, H2O

Organic Chemistry: A Guided Inquiry

2nd Edition

ISBN:9780618974122

Author:Andrei Straumanis

Publisher:Andrei Straumanis

Chapter26: Aldol And Claisen Reactions

Section: Chapter Questions

Problem 26E

See similar textbooks

Similar questions

Complete the synthesis of the following compound from the starting material given (2- oxocyclohexane-1-carbaldehyde). Over/next to the reaction arrows, list out all reagents/solvents used. Draw intermediate structures in the boxes. You may use as many steps as you think necessary. You do NOT have to draw the mechanisms.
The question is: "Draw the curved arrow mechanism for the reaction between pentan-2-one and (CH3)3O– in t-butanol to form an enolate. Draw all electrons and charges on both resonance structures. Then answer the question about the reaction." I got the initial arrows correct, but am not entirely sure what the carbanion intermediate would look like and then what the curved arrows would be to convert it to its final oxanion form
Complete the synthesis of ethyl (E)-2,2,4-trimethyl-3-oxo-5-phenylpent-4-enoate from the starting material given (ethyl propionate). You must list out all reagents/solvents next to the reaction arrows and draw the intermediate structures in the boxes. I am giving you one restriction. You are not allowed to introduce any enolates as reagents next to the reaction arrows. orff ion
The following transformation can be accomplished by reactions we have studied in this chapter and Chapter 20. Name the type of reaction used in each step.
Alcohols react with sulfonyl chlorides to form sulfonate esters. Only the O-H bond of the alcohol is broken in the reaction, and so no inversion of configuration occurs. The resulting sulfonate esters are reactive in SN1 and SN2 reactions since the sulfonate group is a very weak base and is therefore a good leaving group.Draw curved arrows to show the movement of electrons in this step of the mechanism.
show the missing reagents and intermediates in the reaction sequence below
Enamines can serve as enolate surrogates in reactions at the a-carbon. In the reaction sequence, the structures of the enamine addition product – the initial zwitterion and its neutral tautomer – are shown. Draw the structures of the two reactants forming these intermediates, and draw the structure of the final product, obtained via hydrolysis of the neutral intermediate. initial zwitterionic intermediate neutral intermediate tautomerization Reactants H,0 hydrolysis product Draw the two reactants. Draw the hydrolysis product. Select Draw Rings More Erase Select Draw Rings More Erase H H
Acyl transfer (nucleophilic substitution at carbonyl) reactions proceed in two stages via a "tetrahedral intermediate." Draw the tetrahedral intermediate as it is first formed in the following reaction. H3C NH₂ HCI/H₂O reflux • You do not have to consider stereochemistry. • Include all valence lone pairs in your answer. • Do not include counter-ions, e.g., Na+, I, in your answer. • In cases where there is more than one answer, just draw one.
Devise a synthesis of (E)-4-methyl-2-pentene using one of the starting materials and any of the reagents below using the fewest steps possible. If you need fewer than the 3 steps allowed, enter "none" for reagents in the remaining unused steps.
Complete the synthesis of the following compound from the starting material given (acetophenone). Over/next to the reaction arrows, list out all reagents/solvents used. Draw intermediate structures in the boxes. You may use as many steps as you think necessary. You do NOT have to draw the mechanisms. OH
Give the complete mechanism for the following reaction of 2 molecules of acetophenone (shown). Show any molecules used, or given off in the process. Indicate which step is (functionally) irreversible. It is not necessary to show all resonance forms of any enolates involved. 2 PRÅCH Ph CH3 -OH, H2O A ?
Multi-step synthesis. Give the reagents over the arrows and the intermediates between thearrows that are required to synthesize the product compound on the left from the reactant givenon the right for each retrosynthetic analysis.