Oropharyngeal cancer is a disease in which malignant (cancer) cells form in the tissues of the oropharynx. The gold standard to diagnose this disease is through RNA qPCR. In 2011, Schache et al. determined the accuracy of Human Papilloma Virus p16  immunohistochemistry (p16 IHC) in detection of oropharyngeal carcinoma. Results from 200 patients are shown in the table below: see photo Compute for the sensitivity of p16 IHC in diagnosis of oropharyngeal carcinoma.   Source: Schache, A. G., Liloglou, T., Risk, J. M., Filia, A., Jones, T. M., Sheard, J., ... & Sloan, P. (2011). Evaluation of human papilloma virus diagnostic testing in oropharyngeal squamous cell carcinoma: sensitivity, specificity, and prognostic discrimination. Clinical Cancer Research, 17(19), 6262-6271.       82.0%     83.9%     93.2%     94.0%

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Oropharyngeal cancer is a disease in which malignant (cancer) cells form in the tissues of the oropharynx. The gold standard to diagnose this disease is through RNA qPCR.

In 2011, Schache et al. determined the accuracy of Human Papilloma Virus p16  immunohistochemistry (p16 IHC) in detection of oropharyngeal carcinoma. Results from 200 patients are shown in the table below:

see photo

Compute for the sensitivity of p16 IHC in diagnosis of oropharyngeal carcinoma.

 

Source: Schache, A. G., Liloglou, T., Risk, J. M., Filia, A., Jones, T. M., Sheard, J., ... & Sloan, P. (2011). Evaluation of human papilloma virus diagnostic testing in oropharyngeal squamous cell carcinoma: sensitivity, specificity, and prognostic discrimination. Clinical Cancer Research17(19), 6262-6271.

 

   

82.0%

   

83.9%

   

93.2%

   

94.0%

p16 IHC Test
Positive
Negative
TOTAL
Oropharyngeal Squamous
Cell Carcinoma Status
(by RNA qPCR)
Present
Absent
94
18
6
82
100
100
112
88
200
TOTAL
Transcribed Image Text:p16 IHC Test Positive Negative TOTAL Oropharyngeal Squamous Cell Carcinoma Status (by RNA qPCR) Present Absent 94 18 6 82 100 100 112 88 200 TOTAL
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