Peptides.1. Draw the peptide Ala-Glu-Gly-Lys, as it would occur at physiological pH = 7.4.The R groups of Ala and Gly are not acidic or basic, therefore do not have a pka and the chargeon these R groups is therefore independent of pH. Glu is acidic and Lys is basic, therefore thecharge on these amino acids is pH dependent. The pKas are shown below.pKaN-term = 9.0C-term = 3.5Glu4.1Lys = 10.52. Draw a circle around the peptide bonds.3. Label the C-terminus and the N-terminus.4. What is the overall charge on the peptide at pH 7.4?

Amino acids are organic compound having two functional group namely carboxyl and amino group. Some…

Answered: Peptides. 1. Draw the peptide…

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Biochemistry

Peptides. 1. Draw the peptide Ala-Glu-Gly-Lys, as it would occur at physielogical pH=7.4. thave pka and the cha

Anatomy & Physiology

1st Edition

ISBN:9781938168130

Author:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble

Publisher:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble

Chapter24: Metabolism And Nutrition

Section: Chapter Questions

Problem 36CTQ: Amino acids are not stored in the body. Describe how excess amino acids are processed in the cell.

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Concept explainers

Nucleotides

It is an organic molecule made up of three basic components- a nitrogenous base, phosphate,and pentose sugar. The nucleotides are important for metabolic reactions andthe formation of DNA (deoxyribonucleic acid) and RNA (ribonucleic acid).

Nucleic Acids

Nucleic acids are essential biomolecules present in prokaryotic and eukaryotic cells and viruses. They carry the genetic information for the synthesis of proteins and cellular replication. The nucleic acids are of two types: deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). The structure of all proteins and ultimately every biomolecule and cellular component is a product of information encoded in the sequence of nucleic acids. Parts of a DNA molecule containing the information needed to synthesize a protein or an RNA are genes. Nucleic acids can store and transmit genetic information from one generation to the next, fundamental to any life form.

Question

Peptides.
1. Draw the peptide Ala-Glu-Gly-Lys, as it would occur at physiological pH = 7.4.
The R groups of Ala and Gly are not acidic or basic, therefore do not have a pka and the charge
on these R groups is therefore independent of pH. Glu is acidic and Lys is basic, therefore the
charge on these amino acids is pH dependent. The pKas are shown below.
pKa
N-term = 9.0
C-term = 3.5
Glu4.1
Lys = 10.5
2. Draw a circle around the peptide bonds.
3. Label the C-terminus and the N-terminus.
4. What is the overall charge on the peptide at pH 7.4?

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