Answered: Propose a retrosynthetic analysis of…

Propose a retrosynthetic analysis of benzocaine from the starting material shown. Your answer should include both the synthons and the reagents that would be employed in the actual synthesis. H2N

Organic Chemistry

8th Edition

ISBN:9781305580350

Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Chapter11: Ethers, Epoxides, And Sulfides

Section: Chapter Questions

Problem 11.21P: Ethylene oxide is the starting material for the synthesis of 1,4-dioxane. Propose a mechanism for...

See similar textbooks

Related questions

Q: Add curved arrows to show the next step, formation of a peroxy radical by coupling with O2, and…

A: Start by identifying the carbon atoms involved in the reaction. In this case, the 1-bromopropane…

Q: 3. Devise a synthesis of each compound from the indicated starting material, organic compounds…

A: Step 1:Here are each compound's potential syntheses:a. Synthesis of propanol from ethanolEthanol can…

Q: Draw the mechanism for the following reaction. 0 EtOH, HCI

A: Step 1:This reaction is the nucleophilic substitution reaction of carbonyl compound,at first…

Q: 2. A. For the reagents listed below, draw the curved arrow mechanism to show the formation of the…

Q: None

A: Step 1:The number of valence electrons in Sn is 4 as it belongs to group 14. On the other hand, F…

Q: None

A: Step 1: Reduction of nitrile into its corresponding aldehyde using DIBALH.Step 2: Wittig reaction in…

Q: Draw the structure(s) of the major organic product(s) of the following reaction, omitting the…

A: Step 1: In this reaction, a carbonyl compound is reacted with a phosphorus yield, which omits the…

Q: Gallium-67 (t1/2 = 25 hours) is used in the diagnosis of tumors. If a patient ingests a compound…

A: The objective of this question is to determine the amount of Gallium-67 remaining in the patient's…

Q: 2. Show the full mechanism of the formation of ethyl glycopyranoside reacting the sugar molecule…

Q: Please answer in tipping format

A: Diethyl malonate react NaoEt to give carbanion. This carbanion react with dibromo compound to give…

Q: The hero great expert Hand written solution is not allowed.

A: Reaction involved is Pb(SO4)2 + 2Zn -> 2ZnSO4 + Pb.Here Pb(SO4)2 is given in excess means it is…

Q: Question is in image.

Q: None

A: Step 1:To find out the exact molecule from the H-NMR, the following steps are used:According to the…

Q: Calculate the average daily intake of chlorobenzene. The concentration is 4.09E-8 mg/m^3, assume…

A: Conversion of Concentration: The concentration of chlorobenzene is initially given in milligrams per…

Q: O H+ (cyclic ester) HOCH2CH2CH2-C-OH Draw the molecule on the canvas by choosing buttons from the…

Q: 10. Draw the condensed structural formula, or line-angle formula if cyclic for each of the…

A: The objective of the question is to draw the condensed structural formula or line-angle formula for…

Q: Consider the reaction A > B. The initial [A] is 0.10 M. After 1.0 hour, 50% of A has reacted. a.…

A: Approach to solving the question: Detailed explanation: Examples: Key references:

Q: None

A: Given:…

Q: What is the total number of grams of NaOH (formula mass = 40) needed to make 1.0 liter of a 0.20 M…

A: The objective of this question is to calculate the total number of grams of NaOH needed to make a…

Q: 10. The internuclear distance of HF is 0.92 Å. The molecular mass of H is 1.00794m, and F is…

A: The objective of the question is to calculate the rotational energy of a hydrogen fluoride (HF)…

Q: Dimethyl cycloheptene is reacted in a sequence of synthetic steps. Show the compounds formed as…

A: Step 1: 1st reagent will do ozonolysis and convert alkene to aldehyde. Step 2: second reagent is…

Q: Explain theoretically why SN1 of 2-chloro-2- methylpropane with silver nitrate in ethanol/water…

A: If you have any problem let me know here in comment box for this thankyou for your question.

Q: When placing aluminum into sulfuric acid, aluminum sulfate and hydrogen gas is formed. 18.2 g of…

Q: None

A: The reaction shown in the image is a Friedel-Crafts acylation. Friedel-Crafts acylation is a classic…

Q: None

Q: 5 1/1 point The concentration of Ag* in a solution saturated with Ag2C2O4(s) is 2.2x10-4 Calculate…

Q: Payalben

A: The objective of the question is to write the cell notation for the given electrochemical cell. The…

Q: We said that organometallic compounds are often used to make carbon-carbon bonds. Specifically, with…

A: Step 1:Determine the possible functional groups present in the compound. The compound has the…

Q: Consider the common ion effect. The molar solubility of PbBr in a solution that is 0.250 M in NaBr…

Q: What is the product of this acid base reaction assuming

A: Amides in the presence of a strong acid proceed to promote a hydrolysis reaction. When this occurs,…

Q: plz hurry, thanks

A: Step 1: Mechanism of reductive amination Step 2: Follow above solution Step 3: So, → as…

Q: None

A: Reaction: Anti-Markovnikov Addition of HBr to Alkene with Peroxide (ROOR)This reaction represents a…

Q: Problem 6 of 50 Submit Draw a resonance structure that places a pi bond in a different position.…

A: Step 1:In resonance electrons are not fixed in specific bonds but instead are spread out over…

Q: 4) Fill in the blanks. a) LDA b) CN Br THP DIBAL OTHP MCPBA Hydrazine H₂N-NH2 KOH heat dil. HCIO4 OH…

A: Step 1:• firstly LDA ( base ) abstract base and attack on alkyl halide to give respective product.•…

Q: Provide a synthesis of the target molecule. All of the carbon atoms in the final product must come…

A: Step 1: Wittig reaction:Methyl bromide with triphenyl phosphine and n-BuLi gives phosphorus…

Q: Each of the insoluble salts below are put into 0.10 M hydroiodic acid solution. Do you expect their…

A: 1. **Nickel(II) sulfide (NiS)**: - NiS is slightly soluble in water. Hydroiodic acid adds a…

Q: Use the Laplace transform to solve the system of differntial equations. z+y+z+y y(0) = 1 y-2z y = 0…

A: Step 1: Take the Laplace Transform of Both Equations1.1. Apply Laplace transform to the first…

Q: Draw the resonance structure for CH2NO2

Q: calculate activity grams of ferric oxide ions in 1g ferric oxide in 20ml solution.

A: Given:1 gram of ferric oxide (Fe2O3)Volume of solution = 20 mL

Q: Problem 2. Supply the reagents in the correct order needed to accomplish the following…

A: Step 1:Step 2: Step 3: Step 4:

Q: Problem 1: Complete the table. Given the molecular weight range and the number of occurrence for…

A: The degree of polymerization refers to the number of monomer units that make up the polymer chain.If…

Q: None

A: 46. The proton with the highest chemical shift in the molecules is the proton that is directly…

Q: Understanding the optical rotation that we observe in lab is not the same as the specific rotation…

A: here we need to use biot's lawgiven: α= 5.5 l= 1dm c= 0.083 g/ml experimental specific rotation =…

Q: 4. Propose a synthesis for the transformations shown below (no mechanisms needed, just…

A: Here are the proposed syntheses for each transformation: 1. 3-methylbut-1-yne →…

Q: Draw the Lewis structure and describe the bonding in Cr2(CH3COO)4(H2O)2 using MO theory. In the…

A: Step 1:Let's draw the structure for Cr2(CH3COO)4H2O. Since we're using molecular orbital theory,…

Q: Calculate the half-cell potentials for the electrochemical cell created using the standard copper…

A: The Nernst equation relates the standard electrode potential (E∘) to the cell potential (E) under…

Q: Determine the concentration of each ion in solution for the dissolution of Al(OH)3 (Ksp =1.9 *…

A: Dissolution of Al(OH)3 will give:- Al(OH)3⇌Al3+ + 3OH- Using ICE table initial concentration of both…

Q: Reaction mechanism

A: The objective of the question is to understand the reaction mechanism between bromine (Br),…

Q: Recall that the Friedel-Crafts alkylation reaction forms a new C-C bond between an aromatic ring and…

Q: All structure and mechanism I need computer answer

A: Step 1:1. Conversion of alcohol to alkyl halide:Propanol with Potassium tribromide at 0oC gives…

Question

Propose a retrosynthetic analysis of benzocaine from the starting material
shown. Your answer should include both the synthons and the reagents that
would be employed in the actual synthesis.
H2N

Expert Solution

This question has been solved!

Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.

SEE SOLUTION Check out a sample Q&A here

Step by step

Solved in 2 steps with 2 images

SEE SOLUTION Check out a sample Q&A here

Similar questions

Following is a synthesis for toremifene, a nonsteroidal estrogen antagonist whose structure is closely related to that of tamoxifen. (a) This synthesis makes use of two blocking groups, the benzyl (Bn) group and the tetrahydropyranyl (THP) group. Draw a structural formula of each group and describe the experimental conditions under which it is attached and removed. (b) Discuss the chemical logic behind the use of each blocking group in this synthesis. (c) Propose a mechanism for the conversion of D to E. (d) Propose a mechanism for the conversion of F to toremifene. (e) Is toremifene chiral? If so, which of the possible stereoisomers are formed in this synthesis?
Propose a synthesis of the topical anesthetic cyclomethycaine from 4-hydroxybenzoic acid, 2-methylpiperidine, and any other necessary reagents. HN' + HO. НО Cyclomethycaine 4-Hydroxybenzoic acid 2-Methylpiperidine
Reaction of p-nitroaniline with sodium nitrite and hydrochloric acid at 0°C, followed by treatment with N,N-diethylaniline.
The mechanism for acidic hydrolysis of a nitrile resembles the basic hydrolysis, exceptthat the nitrile is first protonated, activating it toward attack by a weak nucleophile (water).Under acidic conditions, the proton transfer (tautomerism) involves protonation on nitrogen followed by deprotonation on oxygen. Propose a mechanism for the acid-catalyzedhydrolysis of benzonitrile to benzamide.
Reaction of p-nitroaniline with sodium nitrite and hydrochloric acid at 0 °C, followed by treatment with N,N-diethylaniline.
The following compound used in perfumery has a violet-like scent. Propose a synthesis of this compound from benzene. 4-Isopropylacetophenone
Phenyl 4-aminosalicylate is a drug used in the treatment of tuberculosis. Propose a synthetic route for this compound starting from 4-nitrosalicylic acid. The synthesis involves multiple steps. Specify all the reagents and the reaction conditions it may require in each step.
The following set of reactions convert phenylacetylene to butylbenzene. Give the appropriate reagents for each step of the following reaction sequence.
Acetic acid has been mixed with isoamyl alcohol to produce isoamyl acetate giving off a banana smell. Propose a reaction mechanism for this reaction.
Provide the necessary reagents to accomplish the desired organic reactions NH HN HO.
Propose a synthesis of the following molecule, starting with cyclohexanone and using any other reagents necessary:
Complete the statements by providing the reagents necessary to complete each step of the synthesis. Ketone reacted with CO₂H and then yielded a derivative, which was treated with 1) (i) C6H5MgBr (ii) H3O+ 2) (i) DIBAL-H (ii). H3O+ 3) Sia2BH,H202, NaOH 4) CH2N2 (diazamethane) CO₂C2H5 5) PCC (an oxidant) 6) H2SO4, H2O, heat 7) HgSO4/ H2SO4 8) C₂H5OH, H3O*, heat TABLE OF REAGENTS to form an unsaturated carboxylic acid, treatment with to yield unsaturated aldehyde as the final product. CHO MacBook Air 9) C6H5 CH2 P(C6H5)3; NaOH 10) PCC (an oxidant) 11) NaCN, H₂SO4 12) PhCH2CHO, H3O*