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- Q10. 1) What is meant by epistasis? The natural colouration of wild mice is called agouti and is produced from banded genes are involved, each with a dominant (A and B) and a recessive allele (a and b). The allele A codes for the ability to produce hair pigment: AA and Aa mice have pigmented hairs but all aa individuals are albinos. The B allele codes for the ability to make hair with grduated colouration: BB and Bb mice have graduated hair, bb mice have hair that is all one colour which is black. hairs. Two2. 235O 4) Q7. Haemophiliacs possess a non-functional form of the gene responsible for the production of blood clotting factors. Shown below is the occurrence of haemophilia in one family. = male = female = male haemophiliac 7. 8. 5. 9. 3. 11 12 Usingthe following symbols: H = dominant allele h = recessive allele 1) State the genotypes of the following individuals. Individual Genotype 1. 6. 2) On the basis of the information provided, is the inheritance of haemophilia: (i) autosomal or sex-linked? (ii) dominant or recessive? 3) State the probability of individual 8 being a carrier of haemophilia. 4) Explain why only females can be carriers of haemophilia.Q17. In a dog breed, a gene B coding for fur color has a dominant allele B for black fur. Gene B has a recessive allele b that produces brown fur. A second gene I, has a dominant allele I that is epistatic to the color locus and can inhibit pigment formation. Gene I has a recessive allele, i, on that permits pigment deposition in the fur. Note: the inhibition of pigment formation by the epistatic allele I causes the fur to be white. A) What is the phenotype of the individuals with the below genotypes? bbii Bbli Bbii bbli BBIi B) What are the phenotypes and genotypes of the offspring of each of these dog crosses? a. bbii x Bbli b. bbii x Bbii c. bbli x BBli C) What type of epistasis is described in this problem? English (United States) Focus F
- 12:27 O Q3. ACTIVITY 2. NONMENDELIAN INHERITANCE 4. If several pea plants with the genotype TTYY are crossed with pea plants with the genotype Tiyy, what percentage of the offipring will be expected to have the TTYY allele combination? 5. In humans, the alleles for blood type are designated I (A-type blood), P (B-type blood) and i (O-lype blood). What are the expected frequencies of phenotypes in the following matings? Draw a Punnett square showing the results for a %AB a) heter A x heter B: b) A" x 1i: e) 11 x I"": di AB xO: $|||| |||| || | | IIy 301 Amelogenesis imperfecta is X-linked dominant. Affected XY individuals have extremely thin enamel on the teeth while XX carriers have grooved teeth from uneven deposition of enamel. If an unaffected XY individual were to produce children with a XX carrier partner, a. what would be the expected chance of a XY child being affected with the disease? b. what would be the expected chance of a XY child being affected with the disease?l Metro by T-Mobile 1 2:29 PM • 16% I In flies, long wings are a dominant trait, and short wings are a recessive trait. Medium wings are the heterozygous trait. Based on this information, if a homozygous long-winged fly is crossed with another a heterozygous'fly, their offspring will have which percentages for long, medium, and short wings? Assume random chromosome segregation. 17) A) 25% long, 75% medium, 0% short B) 50% long, 25% medium, 25% short 50% long, 50% medium, 0% short D) 100% medium, 0% long, 0% short
- а. What type of inheritance is shown in the pedigree? II 2 II 1 2 4 IV Identify the genotypes of the following individuals: III- 2 b. |-1 Il- 2 III-4 IV-1 + v Paragraph В I17. In rats, the following genotypes of two independently assorting autosomal genes determine coat color.A_B_ (gray)A_bb (yellow)aaB_ (black)aabb (cream)A third gene pair on a separate autosome determines whether or not any color will be produced.The CC and Cc genotypes allow color according to the expression of the A and B alleles.However, the cc genotype results in albino rats regardless of the A and B alleles present. Given the inheritance pattern of coat color in rats described in Problem 17, predict the genotype and phenotype of the parents who produced the following offspring: (c) 27/64 gray: 16/64 albino: 9/64 yellow: 9/64 black: 3/64 creamQ11. One of the two genes known to be mutated in cases of Hypokalemic periodic paralysis (which is inherited in an autosomal dominant pattern but known to affect males more often than females) is the calcium voltage-gated channel subunit alpha1 S (CACNA1S). What is known about the gene is recorded here: https://www.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000081248;r=1:201039512-201112451 Please navigate to the link above and ensure that you click to reveal the transcript table. Then use the information in the table to answer the following question. What is the NCBI accession number (including the version) of the RefSeq Match for the first transcript (CACNA1S-201)? Answer: NCBI accession number (including the version) of the RefSeq Match for the first transcript (CACNA1S-201) is ...
- EE³ E²E4 Clear my choice Which of the following statements best describes the inheritance pattern of an X-linked dominant disorder? a. Two unaffected parents can produce an affected child. b. Only daughters of an affected man are affected. c. Only sons of an affected female are affected. O d. Only individuals who are homozygous for the mutated gene are affected. Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is a rare inherited disorder that causes su Which of the following pedigrees shows the inheritance pattern of ARVC/D? O a. OTOThe ABO blood groups in humans are expressed as the IAlB, and IAalleles. The allele encodes the A blood group antigen, lBencodes B, and i encodes O. Both A and B are dominant to O. If a heterozygous blood type A parent (IAi) and a heterozygous blood type B parent (IBi) mate, one quarter of their offspring will have AB blood type (IAIB) in which both antigens are expressed equally. Therefore, ABO blood groups are an example of: multiple alleles and incomplete dominance codominance and incomplete dominance incomplete dominance only multiple alleles and codominance问题13 Achondroplasia (dwarfism) is an example of a dominantly inherited disease. Individuals who have the dominant gene (A) have the dwarfism phenotype, while normal height is recessive (a). What is the probability of having children with achondroplasia between a normal height female and a heterozygote achondroplasia male? 100% 75% 25% 50%
