Questions 11-13 are all based on the following information: Human chromosome 4 is about 215 CM long. SNPs 1 and 2 are two single nucleotide polymorphic loci at opposite ends of this chromosome. Linked at 8 cM from SNP2 is a gene for a recessive form of hot water epilepsy (epilepsy induced by hot water poured on the head; H = healthy, h = epilepsy). The pedigree shows inheritance of the SNPs and of the disorder. SNP alleles were identified by allele- specific oligonucleotide hybridization (shading indicates hybridization). Assume that there is no new mutation or aberrant event in this pedigree. Healthy (HP) 1-1 GG TT TT II-1 AA CC GG TT 1-2 1-3 T 11-2 14 Female Male SNP1 Hot-water epilepsy (hh) H SNP2 8CM 11. Give the egg and sperm genotype (for all three loci) received by II-1 and II-2. No explanations needed. • Genotype of egg received by II-1: . Genotype of sperm received by Il-1: Genotype of egg received by II-2: • Genotype of sperm received by II-2: 12. Epilepsy question continued... A geneticist want to calculate the probability that the first child born to Il-1 and II-2 will have hot-water epilepsy and will also be homozygous at both SNP loci. (No explanations needed for any part of this question.) a. Give the required gamete genotype from II-1 (all three loci). b. Considering H/h and SNP1, is this gamete (from II-1) Parental type (P), Recombinant (R), or unknown status (U)? c. Considering H/h and SNP2, is this gamete (from Il-1) Parental type (P), Recombinant (R), or unknown status (U)? d. Now give the required gamete genotype from II-2 (all three loci). e. Considering H/h and SNP1, is this gamete (from II-2) Parental type (P), Recombinant (R), or unknown status (U)? f. Considering H/h and SNP2, is this gamete (from II-2) Parental type (P), Recombinant (R), or unknown status (U)? 13. Epilepsy question continued... To continue calculating the probability that II-1 and II-2 will have a child with hot- water epilepsy and homozygous for both SNPs... a. What is the probability of of the required gamete from II-1? Show the steps in your calculation. b. What is the probability of of the required gamete from II-2? Show the steps in your calculation. c. What is the overall probability of this child? (Just set up the equation, no need to calculate the final value.)

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
icon
Related questions
Topic Video
Question
This is not a writing assignment. The information is given. I’m confused for this since there are 3 parts associated with the question.
General information:
Genotype format: Use a forward-slash ('7') to separate homologues and
semi-colons (';') to separate chromosomes.
GH Ef
For example, to depict the hypothetical genotype
gh
eF
.you would write: GH / gh ; Ef / eF
Or in the case of X-linked loci you would write (for example)XAb/ xaB or XAb/Y.
If (for example) Gand Hare not linked or if you don't know whether they are linked
you can just write that genotype as Gg Hh or G/g H/h.
For haploid gametes just write out the alleles on one line (e.g., a gamete made by
GH / gh could be Gh and a gamete made by XAb/ xaB could be XAb).
Transcribed Image Text:General information: Genotype format: Use a forward-slash ('7') to separate homologues and semi-colons (';') to separate chromosomes. GH Ef For example, to depict the hypothetical genotype gh eF .you would write: GH / gh ; Ef / eF Or in the case of X-linked loci you would write (for example)XAb/ xaB or XAb/Y. If (for example) Gand Hare not linked or if you don't know whether they are linked you can just write that genotype as Gg Hh or G/g H/h. For haploid gametes just write out the alleles on one line (e.g., a gamete made by GH / gh could be Gh and a gamete made by XAb/ xaB could be XAb).
Questions 11-13 are all based on the following information:
Human chromosome 4 is about 215 cM long. SNPS 1 and 2 are two single
nucleotide polymorphic loci at opposite ends of this chromosome. Linked at 8 cM
from SNP2 is a gene for a recessive form of hot water epilepsy (epilepsy induced
by hot water poured on the head; H = healthy, h = epilepsy). The pedigree shows
inheritance of the SNPS and of the disorder. SNP alleles were identified by allele-
specific oligonucleotide hybridization (shading indicates hybridization). Assume
that there is no new mutation or aberrant event in this pedigree.
1-1
1-2
14
Healthy (H?)
Hot-water epilepsy (hh)
Female Male
GG
GG
SNP1
H SNP2
II-2
8 cM
GG
11. Give the egg and sperm genotype (for all three loci) received by II-1 and Il-2.
No explanations needed.
• Genotype of egg received by II-1:
• Genotype of sperm received by II-1:
• Genotype of egg received by II-2:
• Genotype of sperm received by II-2:
12. Epilepsy question continued...
A geneticist want to calculate the probability that the first child born to II-1 and II-2
will have hot-water epilepsy and will also be homozygous at both SNP loci. (No
explanations needed for any part of this question.)
a. Give the required gamete genotype from II-1 (all three loci).
b. Considering H/h and SNP1, is this gamete (from II-1) Parental type (P),
Recombinant (R), or unknown status (U)?
c. Considering H/h and SNP2, is this gamete (from Il-1) Parental type (P),
Recombinant (R), or unknown status (U)?
d. Now give the required gamete genotype from II-2 (all three loci).
e. Considering H/h and SNP1, is this gamete (from II-2) Parental type (P),
Recombinant (R), or unknown status (U)?
f. Considering H/h and SNP2, is this gamete (from II-2) Parental type (P),
Recombinant (R), or unknown status (U)?
13. Epilepsy question continued...
To continue calculating the probability that II-1 and II-2 will have a child with hot-
water epilepsy and homozygous for both SNPS...
a. What is the probability of of the required gamete from II-1? Show the steps in
your calculation.
b. What is the probability of of the required gamete from Il-2? Show the steps in
your calculation.
c. What is the overall probability of this child? (Just set up the equation, no need
to calculate the final value.)
Transcribed Image Text:Questions 11-13 are all based on the following information: Human chromosome 4 is about 215 cM long. SNPS 1 and 2 are two single nucleotide polymorphic loci at opposite ends of this chromosome. Linked at 8 cM from SNP2 is a gene for a recessive form of hot water epilepsy (epilepsy induced by hot water poured on the head; H = healthy, h = epilepsy). The pedigree shows inheritance of the SNPS and of the disorder. SNP alleles were identified by allele- specific oligonucleotide hybridization (shading indicates hybridization). Assume that there is no new mutation or aberrant event in this pedigree. 1-1 1-2 14 Healthy (H?) Hot-water epilepsy (hh) Female Male GG GG SNP1 H SNP2 II-2 8 cM GG 11. Give the egg and sperm genotype (for all three loci) received by II-1 and Il-2. No explanations needed. • Genotype of egg received by II-1: • Genotype of sperm received by II-1: • Genotype of egg received by II-2: • Genotype of sperm received by II-2: 12. Epilepsy question continued... A geneticist want to calculate the probability that the first child born to II-1 and II-2 will have hot-water epilepsy and will also be homozygous at both SNP loci. (No explanations needed for any part of this question.) a. Give the required gamete genotype from II-1 (all three loci). b. Considering H/h and SNP1, is this gamete (from II-1) Parental type (P), Recombinant (R), or unknown status (U)? c. Considering H/h and SNP2, is this gamete (from Il-1) Parental type (P), Recombinant (R), or unknown status (U)? d. Now give the required gamete genotype from II-2 (all three loci). e. Considering H/h and SNP1, is this gamete (from II-2) Parental type (P), Recombinant (R), or unknown status (U)? f. Considering H/h and SNP2, is this gamete (from II-2) Parental type (P), Recombinant (R), or unknown status (U)? 13. Epilepsy question continued... To continue calculating the probability that II-1 and II-2 will have a child with hot- water epilepsy and homozygous for both SNPS... a. What is the probability of of the required gamete from II-1? Show the steps in your calculation. b. What is the probability of of the required gamete from Il-2? Show the steps in your calculation. c. What is the overall probability of this child? (Just set up the equation, no need to calculate the final value.)
Expert Solution
steps

Step by step

Solved in 2 steps

Blurred answer
Knowledge Booster
Mitochondrial mutations
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.
Similar questions
  • SEE MORE QUESTIONS
Recommended textbooks for you
Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:
9780134580999
Author:
Elaine N. Marieb, Katja N. Hoehn
Publisher:
PEARSON
Biology 2e
Biology 2e
Biology
ISBN:
9781947172517
Author:
Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:
OpenStax
Anatomy & Physiology
Anatomy & Physiology
Biology
ISBN:
9781259398629
Author:
McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:
Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:
9780815344322
Author:
Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:
W. W. Norton & Company
Laboratory Manual For Human Anatomy & Physiology
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:
9781260159363
Author:
Martin, Terry R., Prentice-craver, Cynthia
Publisher:
McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)
Inquiry Into Life (16th Edition)
Biology
ISBN:
9781260231700
Author:
Sylvia S. Mader, Michael Windelspecht
Publisher:
McGraw Hill Education