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- Aromatic substitution reactions occur by addition of an electrophile such as Br+ to an aromatic ring to yield an allylic carbocation intermediate, followed by loss of H+. Show the structure of the intermediate formed by reaction of benzene with Br+.8-6 Propose a mechanism for the following reaction.105 CH3 CH3 H;C- CH3 HC, PMe, (2 equiv.) H,C "CH3 PHCH, "CH3 PMey H,C H,C Me P How to draw the mechanism?Synthesize the following compound using only benzene and 3-hexyne as sources for carbon O OH
- The structure shown below is of Pitolisant (Waxix®), is a drug to treat narcolepsy. CI Pitolisant – Waxix® Below, see the synthesis of the compound. What are the reactions used? OMs OH OH CI CI O Two Williamson ether synthesis reactions. O Aminal formation followed by an ether interchange reaction. O An SN2 reaction followed by a Williamson synthesis.How can you prepare the following compounds with benzene as one of the starting materials?3. Propose a mechanism for the following reaction: H₂SO4 H₂O HOR HO
- 3. Provide a mechanism for the following transformation: H3C. HO HCI CH3OH HC ✓ LOCH, * HO 4. Provide a mechanism for the following transformation: A NaOH H2N + H₂O, A O Na5- Provide a concise synthesis for the following compound starting from benzene: Orther IPSO SO₂H ortho Para meta CI NO₂4. How would you make the target compounds from the given starting materials? Please provide reaction conditions. a) OH b) Me H3C CH3 Me H.