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- (a) Enter the parent phenotypes and complete the Punnett square Inheritance of sex linked recessive tralts Example: Hemophilia Female paront phenotype Inheritance of hemophilia is sex linked. Males with the recessive (hemophilia) allele, are affected. Females can be carriers. (normal female) Xxh (carrier female) ben-N werxhxh (hemophiliac female) leizobXY (normal male) xhy (hemophiliac male) Male parent phenotype: Using the codes: XX eggs (a) Enter the parent phenotypes and complete the Punnett square for a cross between a normal male and a carrier female. sperm (b) Give the ratios for the phenotypes from this cross. Phenotype ratios: Inheritance of sex linked dominant traits Example: Sex linked form of rickets A rare form of rickets is inherited on the X chromosome. Using the codes: XX Female parent phenotype: alvo eo (normal female); XY (normal male) (affected heterozygote female) XRXR (affected female) XRY Male parent phenotype: XRX eggs (affected male) Nor a cross between an…The pedigree shown below shows the inheritance of cystic fibrosis, a disorder that causes severe damage to the lungs and digestive system. Individual 5 shows no family history of cystic fibrosis and is considered to be homozygous for the normal allele. What is the probability that individual 10 is a carrier for the allele leading to cystic fibrosis?Marfan syndrome is a rare inherited human disorder characterizedby unusually long limbs and digits plus defects in the heart (especially the aorta) and the eyes, among other symptoms. Following isa pedigree for this disorder. Affected individuals are shown withfilled (black) symbols. What type of inheritance pattern do youthink is the most likely?
- Above is a pedigree for colorblindness. Based on the pedigree, is the disease dominant or recessive and is it sex-linked or autosomal? Why? Furthermore, what is the probability that 18 on this chart is affected but the condition, and what is the probability that 18 is a carrier? Why? Are the probability of being a carrier and an affected individual different? WhyRefer to the pedigree below which shows inheritance for achondroplasia (dwarfism), a dominantly inherited trait (denoted as D), which are the darkened circles and squares. Dwarfism (darkened shapes) are dominantly inherited, while normal height is recessively inherited (hh). Based on the pedigree, what is the correct genotype for individual #II-6? Dominant Autosomal Pedigree 2 II 2 3 II 1 2 3 6 9 10 Dd DD DD or Dd ddConsider the pedigree below for the hairy toes trait, denoted with the gene symbols H and h (if autosomal), or XH and Xh (if X-linked) and answer the questions below. I = E 1 1 O 2 2 3 Autosomal Recessive 2 X-linked Dominant 3 X-linked Recessive 5 6 Which modes of inheritance are possible? (Indicate yes or no with Y or N) Autosomal Dominant 4 5 4 5 6
- In this case a family history revealed a genetic basis for the disorder. The pedigree is shown in Fig. 1 Below. Key Ø Female: affected Female: unaffected || IV V 5600 orize 077808 15 10 9 10 CHO વ Male: affected Male: unaffected Deceased Disease status not given Dizygotic twins Monozygotic twins Fig. 1 Disease pedigree. Five generations I, II, III, IV, V are shown. Females are represented by circles, males by squares, dizygotic (non-identical) twins by diagonal lines originating from the same point, Monozygotic (identical) twins by diagonal lines originating from the same point and joined symbols and deceased by a diagonal line through the symbol. Filled symbols indicate that the individual displays the disease phenotype. Unfilled symbols indicate that the individual does not display the disease phenotype. Carriers of the disease are not indicated. Information on disease status is not known for generation I and is omitted for the individuals represented by a symbol with an asterisk.…The following pedigree shows a family in which an inherited condition is apparent. The muscle biopsy from the one of the affected persons shows ragged red fibers and parking lot inclusions on microscopy. What is the most likely mode of inheritance for this condition? Answers A - E A Autosomal Dominant B Autosomal Recessive C Mitochondrial D X-linked Dominant E X-linked Recessive O O TO 0 ☐ QAcatalasia is caused by a rare autosomal recessive gene. In heterozygous condition catalase activity is decreased slightly. A woman with a normal catalase activity have a husband with low catalase activity. What is the probability of children birth without anomaly in the family, if grandparents from both sides have reduced activity of catalase? Diagram the cross and mention the genotypes of all individuals in the family?
- What is the most likely inheritance pattern shown in image B, below? B A E KEY Homozygous Homozygous Heterozygous Heterozygous Wild Type Male Female Male Female Male Note: Completely red symbol denotes an individual exhibiting the phenotype of interest CI 11 III IV V 1/4 A Autosomal Dominant Autosomal Recessive Sex-linked Dominant Sex-Linked Recessive Mitochondrial 1/2 1/2 1/2 1/2 Wild Type Female 1/4 1/2 B Affected Known carrier Affected female Normal female Affected male Normal maleIn the pedigree below what is the most likely mode of inheritance? Assume the phenotype of interest is rare. Group of answer choices 1 X-linked recessive 2 Mitochondrial 3 Autosomal recessive 4 X-linked dominant 5 Autosomal dominant 6 Y-linkedThe pedigree below shows a family tree for hemophilia, which is a sex-linked recessive disorder. 21 10 11 12 13 14 If individual 14 had a child with a man who has hemophilia what is the probability that any of thei 0% O 25% O 50% O 100%