Select statements that accurately describe receptor tyrosine kinases (RTKs). Some RTKs are dimeric in the presence of a ligand. GTPase activity is required for autophosphorylation (cross-phosphorylation). The structure includes a transmembrane helix. The intracellular domain has kinase domains. The a subunit contains seven a helices that span the membrane. A ligand binds to the extracellular domain.

Select statements that accurately describe receptor tyrosine kinases (RTKs). Some RTKs are dimeric in the presence of a ligand. GTPase activity is required for autophosphorylation (cross-phosphorylation). The structure includes a transmembrane helix. The intracellular domain has kinase domains. The a subunit contains seven a helices that span the membrane. A ligand binds to the extracellular domain.

Biology 2e

2nd Edition

ISBN:9781947172517

Author:Matthew Douglas, Jung Choi, Mary Ann Clark

Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark

Chapter9: Cell Communication

Section: Chapter Questions

Problem 1VCQ: Figure 9.8 HER2 is a receptor tyrosine kinase. In 30 percent of human breast cancers, HER2 is...

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Figure 9.8 HER2 is a receptor tyrosine kinase. In 30 percent of human breast cancers, HER2 is permanently activated, resulting in unregulated cell division. Lapatinib, a drug used to treat breast cancer, inhibits HER2 receptor tyrosine kinase autophosphorylation (the process by which the receptor adds phosphates onto itself), thus reducing tumor growth by 50 percent. Besides autophosphorylation, which of the following steps would be inhibited by Lapatinib? Signaling molecule binding, dimerization, and the downstream cellular response. Dimerization, and the downstream cellular response. The downstream cellular response. Phosphatase activity, dimerization, and the downsteam cellular response.
Outline the three general means by which binding of a water soluble extracellular chemical messenger to its matching surface membrane receptor brings about the desired intracellular response.
A ligand binds to the extracellular portion of a receptor. Another ligand binds to an identical half of the same receptor. When this happens, the two halves come together and the intracellular portion adds phosphates from ATP to tyrosine amino acids it the receptor structure. This passage describes what kind of receptor? Select one: a. A G-protein coupled receptor b. A receptor tyrosine kinase c. A receptor tyrosine phosphatase d. A ligand-gated kinase channel
Which of the following residues cannot be phosphorylated by a protein kinase? Ser His Thr Tyr Glu
All except which one of the following can be a function of the heterotrimeric G protein of a GPCR? a) inhibit adenylyl cyclase b) activate adenylyl cyclase c) act as a protein kinase d) activate ion channels
. Protein kinase A is activated by: phosphorylation of its catalytic subunit phosphorylation of its regulatory subunits binding of cAMP to its catalytic subunits binding of cAMP to its regulatory subunits
when a chemical messenger (or ligand) reaches a target cell, it binds to a receptor. A hydrophobic ligand binds to a(n) _______, whereas a hydrophilic ligand binds to a(n)_________. a. agonist receptor; antagonic receptor b. transmembrane receptor; intracellular receptor c. antagonist receptor; agonist receptor d. intracellular receptor; transmembrane receptor
Which of the following is an example of heterodimeric protein?a) Integrinb) Antibodiesc) Receptor tyrosine kinased) G-protein coupled receptor
Which of the following regarding GPCR's is FALSE? GPCR ligand binding stimulates phosphorylation of the heterotrimeric G protein GPCR's have seven transmembrane domains The alpha subunit of the heterotrimeric G protein is active in its GTP bound state The beta-gamma subunit of the heterotrimeric G protein performs signaling functions
. which of the following statements about heterotrimetric G proteins and their receptors is incorrect? A: when GTP binds to the alpha subunit of the G protein, the beta-gamma subunit dissociates from the alpha subunit B: G-protein coupled receptors contain nine transmembrane alpha helices C: binding of arrestin causes removal of the receptor from the membrane D: G protein- coupled receptors may be desensitized by serine phosphorylation I had chosen option A and got it wrong. What is the Correct answer and explain how it is. Also, where did i go wrong in choosing option A?
Draw a diagram of a membrane receptor and include the following details. Include a depiction of the plasma membrane with which it is associated; label the locations of the extracellular space, the cytoplasm, and the ligand-binding domain.
The G protein coupled receptor (GPCR) pathway elicits diverse intracellular responses in different cells. The basic steps of GPCR signaling are outlined in this diagram. Which of the following statements correctly describes the process of GPCR signaling? The GPCR activation is reversible after the signal of the ligand diminishes. The membrane-embedded enzyme uses GTP as a secondary messenger to initiate gene expression. The ligand attaches to both the GPCR and the membrane-embedded enzyme to activate the GPCR pathway. The ligand-bound GPCR sends a GTP molecule to an enzyme in the membrane and switches it into an active state.