sotopes Ag107 to Ag. Its mean is 1.076, and measurements m sample of observed isotopic abundance ratios suggested tha plausibly normally distributed with a sample standard n of 0.0026. Interest in this part of the question concerns the g of a further experiment to detect whether this ratio is differ vations from a certain source of silver nitrate. v study will use a two-sided test at the 5% significance level, ng normality. It is desired to make sufficient observations of tl abundance ratio on the silver nitrate so that the power of th distinguish a difference between the mull hypothesis of a true ing mean of 1.076 and a value that is 0.0015 larger or 0.0015 is 90%. For the purpose of performing the necessary sample : ion, it will be assumed that the population standard deviation opic abundance ratio measurements is equal to the sample d deviation given above. lculate, by hand, the size of the sample required to achieve th ired power of the test. Show your working.

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The isotopic abundance ratio of natural silver (Ag) is the ratio of the
stable isotopes Ag107 to Ag109. Its mean is 1.076, and measurements on
a random sample of observed isotopic abundance ratios suggested that
they are plausibly normally distributed with a sample standard
deviation of 0.0026. Interest in this part of the question concerns the
planning of a further experiment to detect whether this ratio is different
in observations from a certain source of silver nitrate.
The new study will use a two-sided test at the 5% significance level,
assuming normality. It is desired to make sufficient observations of the
isotopic abundance ratio on the silver nitrate so that the power of the
test to distinguish a difference between the null hypothesis of a true
underlying mean of 1.076 and a value that is 0.0015 larger or 0.0015
smaller is 90%. For the purpose of performing the necessary sample size
calculation, it will be assumed that the population standard deviation of
the isotopic abundance ratio measurements is equal to the sample
standard deviation given above.
(i) Calculate, by hand, the size of the sample required to achieve the
desired power of the test. Show your working.
(ii) Suppose that it was decided to seek to distinguish between the
underlying mean and values that are two-thirds as much (that is,
0.001) larger or smaller than it (rather than 0.0015). Ignoring
rounding up to an integer, and assuming that no other aspect of
the problem changes, by what factor should the required sample
size be adjusted?
Transcribed Image Text:The isotopic abundance ratio of natural silver (Ag) is the ratio of the stable isotopes Ag107 to Ag109. Its mean is 1.076, and measurements on a random sample of observed isotopic abundance ratios suggested that they are plausibly normally distributed with a sample standard deviation of 0.0026. Interest in this part of the question concerns the planning of a further experiment to detect whether this ratio is different in observations from a certain source of silver nitrate. The new study will use a two-sided test at the 5% significance level, assuming normality. It is desired to make sufficient observations of the isotopic abundance ratio on the silver nitrate so that the power of the test to distinguish a difference between the null hypothesis of a true underlying mean of 1.076 and a value that is 0.0015 larger or 0.0015 smaller is 90%. For the purpose of performing the necessary sample size calculation, it will be assumed that the population standard deviation of the isotopic abundance ratio measurements is equal to the sample standard deviation given above. (i) Calculate, by hand, the size of the sample required to achieve the desired power of the test. Show your working. (ii) Suppose that it was decided to seek to distinguish between the underlying mean and values that are two-thirds as much (that is, 0.001) larger or smaller than it (rather than 0.0015). Ignoring rounding up to an integer, and assuming that no other aspect of the problem changes, by what factor should the required sample size be adjusted?
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