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Suppose the concentration of glucose inside a cell is 0.1 mM and the cell issuspended in a glucose solution of 0.01 mM.(a) What would be the free energy change, in kJ/mol, for the transport ofglucose from the medium into the cell? Assume T = 37 °C.(b) What would be the free energy change, in kJ/mol, for the transport ofglucose from the medium into the cell if the intracellular and extracellularconcentrations were 1 mM and 10 mM, respectively?(c) If the processes described in parts (a) and (b) were coupled toATP hydrolysis, how many moles of ATP would have to be hydrolysed,per mole of glucose transported, in order to make each process favorable? (Use the standard free energy change for ATP hydrolysis.)

Suppose the concentration of glucose inside a cell is 0.1 mM and the cell issuspended in a glucose solution of 0.01 mM.(a) What would be the free energy change, in kJ/mol, for the transport ofglucose from the medium into the cell? Assume T = 37 °C.(b) What would be the free energy change, in kJ/mol, for the transport ofglucose from the medium into the cell if the intracellular and extracellularconcentrations were 1 mM and 10 mM, respectively?(c) If the processes described in parts (a) and (b) were coupled toATP hydrolysis, how many moles of ATP would have to be hydrolysed,per mole of glucose transported, in order to make each process favorable? (Use the standard free energy change for ATP hydrolysis.)

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Suppose the concentration of glucose inside a cell is 0.1 mM and the cell is
suspended in a glucose solution of 0.01 mM.
(a) What would be the free energy change, in kJ/mol, for the transport of
glucose from the medium into the cell? Assume T = 37 °C.
(b) What would be the free energy change, in kJ/mol, for the transport of
glucose from the medium into the cell if the intracellular and extracellular
concentrations were 1 mM and 10 mM, respectively?
(c) If the processes described in parts (a) and (b) were coupled to
ATP hydrolysis, how many moles of ATP would have to be hydrolysed,
per mole of glucose transported, in order to make each process favorable? (Use the standard free energy change for ATP hydrolysis.)

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