T cells develop in the thymus. 90% of all thymocytes do not survive. They die due to apoptosis within the thymus as they may fail to make a productive T cell receptor and fail to survive the thymic selection. Thymocytes need to undergo two selection processes in the thymus. What are these selections? Explain why these processes are necessary.

T cells develop in the thymus. 90% of all thymocytes do not survive. They die due to apoptosis within the thymus as they may fail to make a productive T cell receptor and fail to survive the thymic selection. Thymocytes need to undergo two selection processes in the thymus. What are these selections? Explain why these processes are necessary.

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter17: Genes And The Immune System

Section: Chapter Questions

Problem 4QP

See similar textbooks

Similar questions

The selection process for T cells is more complex than B cells. Please explain the process, why it is more complex, and how/why autoreactive T cells are allowed to leave the thymus.
Whether the statement "To guarantee that the antigen-presenting cells in the thymus will display a complete repertoire of self peptides to allow elimination of self-reactive T cells, the thymus recruits dendritic cells from all over the body" is true or false.
T cells andB cells. Put a check () mark in the table spaces below if the characteristic indicates the lymphocyte type. Put a cross (*) mark if III. otherwise. Characteristics T cell В сell Originates in the bone marrow May give rise to plasma cells Immunocompetence happens in bone marrow May give rise to memory cells Include regulatory, helper, and cytotoxic cells Responsible in directly attacking virus-infected cells Produces antibodies Effective against extracellular pathogens Immunocompetence happens in thymus gland Effective against intracellular pathogens Holds a surface meceptor capable of recognizing a specific antigen
That answer is incorrect. Type 1 immunity does not include parasites (those are type 2). T helper 2 cells (Th2) are also part of type 2 immunity as well as ICL2s, mast cells, eosinophils, basophils, IL-4, IL-5, IL-13, IgA, and IgE (IgG is found in both).
Food-derived retinoic acid and commensal bacteria stimulate all three populations of innate lymphoid ells(ILC, ILC2, ILC3) to cause T cell inactivation (anergy) and regulatory T cell (Treg) formation. True False
Thymus: (a) the functional morphology (structure, cellular composition/arrangement, and related functions) of the thymus; and (b) each step in the T cell maturation process.
New Skin' research center uses mice for studies of skin grafting. To prevent rejection of the graft, the mice are thymectomized (taking out thymus) at birth. Even though B cells do not develop in the thymus, these mice show no humoral immune response and are very susceptible to infection. Explain why the removal of the thymus would improve the success of skin grafts but adversely affect humoral immunity.
Which isoform of thymic stromal lymphopoeitin (TSLP) induces inflammatory effects? long form O neither O both short form
Match the term with its correct description. selection for thymocytes which recognize self MHC molecules elimination of thymocytes which recognize self continued alpha chain rearrangement until a functional TCR is generated process by which autoreactive thymocytes are eliminated in the thymus activation of a T-cell only if the appropriate MHC molecule presents an antigenic peptide ✓Choose... Apoptosis MHC restriction Positive selection Negative selection T-cell receptor editing Choose...
"To guarantee that the antigen-presenting cells in the thymus will display a complete repertoire of self peptides to allow elimination of self-reactive T cells, the thymus recruits dendritic cells from all over the body is true or false.
The T lymphocytes as macrophages, secrete a number of polypeptides (cytokines) generally called lymphokines that serve as autocrine regulators of the immune system. Identify any five (5) lymphokines and explain their functions.
The T cell subset recognized as as comprising the tissue-resident memory cell population in the mouse parenchyma is Treg cells CD4+ T cells O CD8+ T cells