Table1.Contractionofsmoothmusclebythreeagonists Contractileresponse(mm) Log[agonist] (M) -10 -9 -8.5 -8 -7.5 -7 -6.5 -6 -5.5 -5 -4.5 -4 agonist-1 0.2 1.8 4 9.8 14.8 18 19.6 19.4 20 20 20 20 agonist-2 0.2 1 2.6 4 7.6 8.8 9.6 9.8 10 10 agonist-3 0.2 2 10 14.8 18 19.6 20 a) Experiments were performed on the contraction of smooth muscleusingincreasingconcentrationsofthreeagonistsandtherespo nsesare given in Table 1. The maximum response of the system was 20mm contraction. Calculate the % maximum response of the systemforeachconcentrationofagonistandplotgraphsshowingthede pendence of the response on log [agonist). Compare the threeagonists in terms of their maximal effect and their potency usingpharmacologicalterms. EN 5. lo

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Problem 2CT: After death, calcium pumps no longer function and the calcium ion concentration of muscle fiber...
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Table1.Contractionofsmoothmusclebythreeagonists
Contractileresponse(mm)
Loglagonist]
(M)
-10
-9
-8.5
-8
-7.5
-7
-6.5
-6
-5.5
-5
-4.5
-4
agonist-1
0.2
1.8 4
9.8 14.8
18
19.6
19.4
20
20
20
20
agonist-2
0.2
1
2.6
4
7.6
8.8
9.6
9.8
10
10
agonist-3
0.2
2
5.2
10
14.8
18
19.6
20
a) Experiments were performed on the contraction of smooth
muscleusingincreasingconcentrationsofthreeagonistsandtherespo
nsesare given in Table 1. The maximum response of the system
was 20mm contraction. Calculate the % maximum response of the
systemforeachconcentrationofagonistandplotgraphsshowingthede
pendence of the response on log [agonist]. Compare the
threeagonists in terms of their maximal effect and their potency
usingpharmacologicalterms.
EIN 5
Transcribed Image Text:Table1.Contractionofsmoothmusclebythreeagonists Contractileresponse(mm) Loglagonist] (M) -10 -9 -8.5 -8 -7.5 -7 -6.5 -6 -5.5 -5 -4.5 -4 agonist-1 0.2 1.8 4 9.8 14.8 18 19.6 19.4 20 20 20 20 agonist-2 0.2 1 2.6 4 7.6 8.8 9.6 9.8 10 10 agonist-3 0.2 2 5.2 10 14.8 18 19.6 20 a) Experiments were performed on the contraction of smooth muscleusingincreasingconcentrationsofthreeagonistsandtherespo nsesare given in Table 1. The maximum response of the system was 20mm contraction. Calculate the % maximum response of the systemforeachconcentrationofagonistandplotgraphsshowingthede pendence of the response on log [agonist]. Compare the threeagonists in terms of their maximal effect and their potency usingpharmacologicalterms. EIN 5
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