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The concentration of the synthetic opioid fentanyl should be determined in a blood plasma sample from a person who has taken an overdose. Outline how to proceed to analyze fentanyl in the plasma sample: Extraction and purification, concentration and analysis (chromatographic technique, column, detector, mobile phase etc.). Fentanyl is approx. 100 times stronger than morphine. Pure fentanyl is a solid with a melting point of 87.5° C. The molecular formula is C22H28N20. The compound is sparingly water soluble (0.024 g / L) with LogP = 3.9. The compound is further weakly basic with a pka value equal to 8.77 (the amino group). The structure of fentanyl is shown in the figure below. Figure 2: The structure of the synthetic opioid fentanyl.

The concentration of the synthetic opioid fentanyl should be determined in a blood plasma sample from a person who has taken an overdose. Outline how to proceed to analyze fentanyl in the plasma sample: Extraction and purification, concentration and analysis (chromatographic technique, column, detector, mobile phase etc.). Fentanyl is approx. 100 times stronger than morphine. Pure fentanyl is a solid with a melting point of 87.5° C. The molecular formula is C22H28N20. The compound is sparingly water soluble (0.024 g / L) with LogP = 3.9. The compound is further weakly basic with a pka value equal to 8.77 (the amino group). The structure of fentanyl is shown in the figure below. Figure 2: The structure of the synthetic opioid fentanyl.

Curren'S Math For Meds: Dosages & Sol
Curren'S Math For Meds: Dosages & Sol
11th Edition
ISBN:9781305143531
Author:CURREN
Publisher:CURREN
Chapter10: Reconstitution Of Powdered Drugs
Section: Chapter Questions
Problem 7.2P
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The concentration of the synthetic opioid fentanyl should be determined in a blood plasma sample from a person who has taken an overdose. Outline how to proceed to analyze fentanyl in the plasma sample: Extraction and purification, concentration and analysis (chromatographic technique, column, detector, mobile phase etc.). Fentanyl is approx. 100 times stronger than morphine. Pure fentanyl is a solid with a melting point of 87.5 ° C. The molecular formula is C22H28N20. The compound is sparingly water soluble (0.024 g / L) with LogP = 3.9. The compound is further weakly basic with a pka value equal to 8.77 (the amino group). The structure of fentanyl is shown in the figure below. -N Figure 2: The structure of the synthetic opioid fentanyl.
Transcribed Image Text:The concentration of the synthetic opioid fentanyl should be determined in a blood plasma sample from a person who has taken an overdose. Outline how to proceed to analyze fentanyl in the plasma sample: Extraction and purification, concentration and analysis (chromatographic technique, column, detector, mobile phase etc.). Fentanyl is approx. 100 times stronger than morphine. Pure fentanyl is a solid with a melting point of 87.5 ° C. The molecular formula is C22H28N20. The compound is sparingly water soluble (0.024 g / L) with LogP = 3.9. The compound is further weakly basic with a pka value equal to 8.77 (the amino group). The structure of fentanyl is shown in the figure below. -N Figure 2: The structure of the synthetic opioid fentanyl.
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