The following structure is more active than morphine as an analgesic. H3C. CH3 H. H3C What is the principal reason for this? O l.
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- The following structure is more active than morphine as an analgesic. H3C CH3 H. H3C' O Il.. What is the principal reason for this? The extra acetyl group binds to cell surface receptors improving active internalization. The acetyl groups mask a polar group allowing the structure to cross the blood brain barrier more efficiently. The extra acetyl group masks an alcohol group which would otherwise undergo a phase Il metabolic conjugation reaction leading to rapid excretion of the drug. The acetyl groups increase the stability of the drug in the cellular environment. O Il..Hi, I need help to find at least three synthesis pathway from simplest hydrocarbon of Dopamine. Thank you so much.Regarding the mechanism of action of chymotrypsin, the formation of a strong hydrogen bond with the hydroxyl group (serine amino acid) increase its: Basicity Nucleophilicity All the answers are correct Electron density
- Which of these heterocyclic drugs is likely to be the least soluble in water? Use the Fsp³ parameter to decide. OH Tramadol Chemical Formula: C16H25NO2 YOUR OW Pantoprazole Torasemide Chemical Formula: C16H15F2N3O4S Chemical Formula: C16H20N4O3S Temazepam -OH Chemical Formula: C16H13CIN₂O2 Tioconazole Chemical Formula: C16H13C3N₂OS A. Tramadol B. Pantoprazole C. Torasemide D. Temazepam E. ToconazoleThink about what part of chymotrypsin, according to our coverage, most contributes to stabilization of the transition state. This contributor is best identified as: Othe acid/base catalystWhat are the similarities and differences (*in terms of structure) between this analgesic and aspirin? What are the major advantage of this analgesic? Structure of analgesic is provided, please draw structure of aspirin too.
- Break down + function Acetyichaline.(Ach) receptors (eacn Fort)Which of the following statements is not true about the catalytic triad in chymotrypsin? Group of answer choices the side chain of the serine 195 is hydrogen bonded to the imidazole ring of histidine the -NH group of the imidazole ring of histidine is hydrogen bonded to the carboxylate group of aspartate 102 the histidine residue serves to position the aspartate 102 side chain and to polarize its carboxylate group so that it is poised for deprotonation histidine acts as a general base catalyst none of these-HO- CH3 .N. .CH3 H3C, `N' HO CH3 CH3 Acetylsalicylic acid (Aspirin) O Briefly propose a procedure (or flow chart) on how to separate a mixture of acetaminophen, Acetaminophen Caffeine aspirin and caffeine.
- Write the structure of each nucleotide-linked sugar in the pathway shown in FigureGiven the active site and reaction mechanism below, what is the mechanism of irreversible inhibition of the inhibitor provided? Active Site Reaction Mechanism Inhibitor HN 2*Zn но NH2 N- HO, NH2 N. NH NH NH O-H NH3 N. N 'N' NH2 OH OH OH OH Но. но. но. но 'N. OH OH OH OH N. HO- Но OH Affinity-based Transition state analog Mechanism-based Uncompetitive Non-specificWhich statement on the biosynthesis of cannabinoids is NOT TRUE? Select one: O a. Geranyl pyrophosphate is formed as a precursor via the deoxyxylulose pathway in cannabis O b. Divarinic acid is the precursor for the production of propyl cannabinoid acids. O C. When prenyl-transferase enzyme uses olivetolic acid as substrate cannabigerivarinic acid (CBGVA) is formed. O d. THCA-synthase, CBDA-synthase, and CBC- synthase enzymes can use both CBGA and GBGVA as substrate.
